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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

102
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

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Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
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Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

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Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
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Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
85
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

149
Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
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Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Updated: Mar 26, 2026

Microinjectrode System for Combined Drug Infusion and Electrophysiology
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Controlled Drug Delivery Using Microdevices.

Sharma T Sanjay, Maowei Dou, Guanglei Fu

  • 1Department of Chemistry, Faculty of University of Texas at El Paso, 500 West University Ave, El Paso, Texas 79968, USA. xli4@utep.edu.

Current Pharmaceutical Biotechnology
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PubMed
Summary

Micro/nanofluidic technologies offer advanced controlled drug delivery, improving drug concentration at pathological sites. These systems overcome limitations of conventional methods by localizing drug activity and enhancing therapeutic efficacy.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmacology

Background:

  • Systemic drug administration faces challenges like poor drug distribution, enzymatic degradation, and rapid excretion, leading to suboptimal therapeutic concentrations.
  • Conventional drug delivery methods often fail to achieve targeted delivery and desired release kinetics, impacting drug efficacy and patient outcomes.
  • Biological barriers and systemic circulation limit the effectiveness of therapeutic drugs by reducing their concentration at pathological sites.

Purpose of the Study:

  • To review recent advancements in controlled drug delivery systems utilizing microfluidic and nanofluidic technologies.
  • To explore the potential of micro/nanofluidics in overcoming the limitations of conventional drug delivery methods.
  • To discuss the integration of various drug delivery components within micro/nanofluidic devices for enhanced therapeutic outcomes.

Main Methods:

  • Review of microreservoir-based drug delivery systems.
  • Highlighting different types of microneedles for controlled drug delivery.
  • Discussion of micro/nanofluidic chip integration for drug delivery components.

Main Results:

  • Micro/nanofluidic technologies enable precise control over drug release rates and localization.
  • Microreservoir systems and microneedles show promise for targeted and efficient drug delivery.
  • Integration of components on micro/nanofluidic chips allows for sophisticated drug delivery system design.

Conclusions:

  • Micro/nanofluidic technologies represent a significant advancement in controlled drug delivery, offering improved therapeutic potential.
  • These technologies provide novel platforms for overcoming conventional drug delivery challenges, enhancing drug efficacy and safety.
  • Future prospects include further development and integration of micro/nanofluidic systems for personalized and effective drug therapies.