Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...

Introduction to Electrolytes

Introduction to Electrolytes

In humans, electrolytes play a vital role in various physiological processes. Balancing electrolyte levels is essential for normal body functions; their imbalance can be life-threatening. The major electrolytes include sodium, potassium, chloride, calcium, phosphate, and bicarbonate. They are primarily involved in physiological processes, such as nerve signal transmission, membrane trafficking, muscle contraction, buffering body fluids, and balancing water levels in the body.
Role of Sodium
One...

What is the Skeletal System?

What is the Skeletal System?

Roles of Electrolytes: Calcium and Phosphate

Roles of Electrolytes: Calcium and Phosphate

Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily...

Skeleton and Calcium Homeostasis

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Eldecalcitol and calcium supplementation in Chinese women with postmenopausal osteoporosis: a prospective observational cohort study.

Journal of bone and mineral metabolism·2026

Same author

Unexpected [18F]-fluciclovine hyperuptake in radiation necrosis after proton therapy: illustrative case.

Journal of neurosurgery. Case lessons·2026

Same author

Sustained Improvement in Renal Function with Palopegteriparatide in Adults with Chronic Hypoparathyroidism: 2-Year Results from the Phase 3 PaTHway-Trial.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026

Same author

Impact of physical and chemical parameters on spinoculation for chimeric antigen receptor T cell manufacturing using a quality-by-design approach.

Molecular therapy. Advances·2026

Same author

A carotid web with accumulation of myofibroblasts: a case report.

BMC neurology·2026

Same author

Palopegteriparatide in Japanese adults with hypoparathyroidism: 52-week results from the phase 3 PaTHway Japan trial.

Endocrine journal·2025

Search research articles

Related Experiment Videos

[Pathogenesis of hypophosphatemia].

Yasuhiro Takeuchi¹

¹oranomon Hospital Endocrine Center, Japan.

Clinical Calcium

|January 28, 2016

Summary

This summary is machine-generated.

Chronic hypophosphatemia, a condition affecting phosphate levels, is linked to musculoskeletal disorders. Understanding its causes and symptoms is crucial for accurate diagnosis and treatment of related diseases.

Related Experiment Videos

Area of Science:

Biochemistry
Orthopedics
Endocrinology

Background:

Chronic hypophosphatemia significantly impacts musculoskeletal health.
Patient symptoms like leg pain and weakness are often non-specific, complicating diagnosis.

Purpose of the Study:

To elucidate the pathogenesis of chronic hypophosphatemia.
To detail the clinical features of hypophosphatemia and associated musculoskeletal disorders.

Main Methods:

Literature review on hypophosphatemia and musculoskeletal conditions.
Analysis of clinical case studies and diagnostic challenges.

Main Results:

Hypophosphatemia contributes to various bone and muscle abnormalities.
Delayed diagnosis is common due to vague and overlapping symptoms.

Conclusions:

A deeper understanding of hypophosphatemia's role in musculoskeletal diseases is essential.
Physicians need to recognize subtle signs for timely diagnosis and management.