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A review: HLA and diseases--current status.
1Department of Microbiology and Immunology Medical Faculty, Comenius University, Bratislava, Czechoslovakia.
Journal of Hygiene, Epidemiology, Microbiology, and Immunology
|January 1, 1989
Summary
The human leukocyte antigen (HLA) complex shows polymorphism, linking HLA antigens to various diseases. Despite unclear mechanisms, these associations are valuable for medical diagnosis, therapy, and genetic counseling.
Area of Science:
- Immunogenetics
- Human Molecular Biology
- Medical Genetics
Background:
- The human leukocyte antigen (HLA) complex exhibits significant polymorphism.
- Numerous associations between HLA antigens and various diseases have been identified.
- The precise biological mechanisms underlying these HLA-disease relationships remain largely unknown.
Purpose of the Study:
- To review the most significant HLA-disease associations.
- To highlight the clinical utility of HLA-disease associations in practical medicine.
- To provide an overview of the current understanding of HLA and disease connections.
Main Methods:
- Literature review of established HLA-disease associations.
- Synthesis of findings regarding the clinical applications of HLA typing.
- Discussion of the implications for diagnosis, therapy, and genetic counseling.
Main Results:
- A substantial number of HLA-disease associations have been documented.
- These associations have practical applications in diagnosis and differential diagnosis.
- HLA typing aids in disease prevention strategies and genetic advisory services.
Conclusions:
- HLA-disease associations are clinically relevant despite obscure underlying mechanisms.
- The established HLA-disease links offer significant benefits in patient management.
- Further research is warranted to elucidate the biological basis of these associations.