[Correlation between chromosomal polymorphisms and male sperm quality in population of Jilin Province]

To evaluate the correlation between chromosomal polymorphisms and male sperm quality in Jilin Province.

A total of 2 584 male patients with infertility in Center for Reproductive Medicine, First Bethune Hospital of Jilin University from 2008 to 2013 were enrolled, which semen analysis, chromosomal analysis, Y chromosome microdeletion analysis and serum hormone levels analysis were performed. A total of 602 healthy individuals, 50 fertile individuals with normal kayrotypes, 50 azoospermia patients with normal kayrotypes and 50 oligospermia patients with normal kayrotypes were selected as control groups.

There was no significant difference in the frequency of chromosome polymorphisms between infertile patients and normal control individuals (3.91% (101/2 584) vs 3.16% (19/602), P > 0.05). And there was no significant difference in the frequency of autosomal polymorphisms between infertile patients and normal control individuals (all P > 0.05). The frequency of Yqh-variant was increased by the decrease of sperm count and it appeared a significantly high frequency in azoospermia patients compared with oligospermia patients and sperm count normal patients in the infertile group (57.14% (21/42) vs 24.32% (9/37), 0 (0/13), both P < 0.05). There was no significant difference in the testis volume and serum hormone levels between the infertile patients with chromosomal polymorphisms and patients in control groups with normal kayrotypes (all P > 0.05). The results of PCR amplication indicated that 32.14% (9/28) patients with Yqh ± had Y chromosome microdeletion.

There is no significant correlation between autosomal polymorphisms and male infertility. But Yqh ± may be responsible for Y chromosome microdeletion and male infertility.