Related Experiment Video
Updated: Mar 26, 2026

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
Can a bleaching toothpaste containing Blue Covarine demonstrate the same bleaching as conventional techniques? An in
Andréa Abi Rached Dantas1, Janaina Freitas Bortolatto1, Ávery Roncolato1
1Departamento de Odontologia Restauradora, Faculdade de Odontologia de Araraquara, Universidade Estadual Paulista, Araraquara, SP, Brazil.
Blue Covarine toothpaste showed no significant whitening effect compared to standard whitening toothpaste or a control. Professional bleaching treatments were more effective than the tested toothpastes.
Area of Science:
- Dentistry
- Materials Science
Background:
- Tooth whitening is a popular cosmetic procedure.
- Conventional methods involve peroxides, while newer approaches explore ingredients like Blue Covarine.
Purpose of the Study:
- To compare the in vitro efficacy of a Blue Covarine bleaching toothpaste against conventional peroxide-based bleaching techniques (in-office and at-home).
Main Methods:
- Five groups were tested: Control, Blue Covarine toothpaste, whitening toothpaste without Blue Covarine, 35% hydrogen peroxide (in-office), and 10% carbamide peroxide (at-home).
- Efficacy was measured by color difference (ΔE), luminosity (ΔL), and color axes (Δa, Δb) using reflectance spectroscopy over 21 days.
- Statistical analysis included repeated measures mixed ANOVA and Bonferroni post hoc tests.
Main Results:
- No significant differences in whitening efficacy were observed between the control, Blue Covarine toothpaste, and standard whitening toothpaste groups.
- Both in-office (35% hydrogen peroxide) and at-home (10% carbamide peroxide) bleaching treatments demonstrated significantly higher whitening efficacy compared to the toothpaste groups.
Conclusions:
- Blue Covarine toothpaste does not offer significant whitening benefits over standard whitening toothpaste or a control.
- Neither tested whitening toothpaste achieved efficacy comparable to professional in-office or at-home bleaching treatments.
More Related Videos
03:10Pilot In Vitro Study to Assess Cleaning Ability and Effects of Different Decontamination Methods on Implant Surfaces
Published on: November 21, 2025
03:37Evaluating the Effects of Different Polishing Methods on Color Stability of Dental Restorations in Pediatric Dentistry
Published on: June 6, 2025
Related Concept Videos
Blinding
Effects of EDTA on End-Point Detection Methods
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a...
Blind Procedures