Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA as a Genetic Template02:05

DNA as a Genetic Template

28.6K
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
28.6K
DNA as a Genetic Template02:05

DNA as a Genetic Template

9.9K
9.9K
The DNA Helix01:16

The DNA Helix

161.6K
Overview
161.6K
The DNA Helix01:07

The DNA Helix

31.6K
Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
31.6K
DNA Replication02:40

DNA Replication

64.5K
DNA replication involves the separation of the two strands of the double helix, with each strand serving as a template from which the new complementary strand is copied.  After replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. This is known as semiconservative replication. The resulting DNA molecules have the same sequence and are divided equally into the two daughter cells.
Replication in Prokaryotes
DNA replication...
64.5K
Sanger Sequencing01:57

Sanger Sequencing

778.2K
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
778.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RNA Interference: A Natural Immune System of Plants to Counteract Biotic Stressors.

Cells·2019
Same author

Label-free detection of folic acid using a sensitive fluorescent probe based on ovalbumin stabilized copper nanoclusters.

Talanta·2019
Same author

Assessing and predicting changes of the ecosystem service values based on land use/cover change in Ebinur Lake Wetland National Nature Reserve, Xinjiang, China.

The Science of the total environment·2019
Same author

Jasmonate promotes artemisinin biosynthesis by activating the TCP14-ORA complex in <i>Artemisia annua</i>.

Science advances·2019
Same author

[Composition and Predictive Functional Analysis of Rhizosphere Bacterial Communities in Riparian Buffer Strips in the Danjiangkou Reservoir, China].

Huan jing ke xue= Huanjing kexue·2019
Same author

Antibacterial activity and action mechanism of questin from marine <i>Aspergillus flavipes</i> HN4-13 against aquatic pathogen <i>Vibrio harveyi</i>.

3 Biotech·2019

Related Experiment Video

Updated: Mar 26, 2026

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

4.9K

DNA based arithmetic function: a half adder based on DNA strand displacement.

Wei Li1, Fei Zhang1, Hao Yan1

  • 1Center of Molecular Design and Biomimetics at The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA and Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA. weili6@asu.edu yan_liu@asu.edu.

Nanoscale
|January 28, 2016
PubMed
Summary
This summary is machine-generated.

Researchers developed DNA-based logic gates, including XOR and AND gates, for biomolecular computing. These gates form a half adder circuit, advancing DNA computing for arithmetic operations.

More Related Videos

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
07:50

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Published on: November 25, 2015

15.0K
Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

7.6K

Related Experiment Videos

Last Updated: Mar 26, 2026

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

4.9K
Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
07:50

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Published on: November 25, 2015

15.0K
Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

7.6K

Area of Science:

  • Biomolecular programming
  • Molecular computing
  • DNA nanotechnology

Background:

  • Biomolecular programming leverages biological molecules for computation.
  • DNA's predictable behavior makes it suitable for logic systems.
  • Existing DNA-based logic systems have limitations in arithmetic operations.

Purpose of the Study:

  • To design and implement DNA-based XOR and AND logic gates.
  • To construct a half adder circuit using these DNA logic gates.
  • To advance DNA molecular programming towards universal arithmetic tools.

Main Methods:

  • Utilized DNA strand displacement reactions to create logic gates.
  • Employed single-stranded DNA (ssDNA) as input and output signals.
  • Integrated XOR and AND gates to build a half adder circuit.

Main Results:

  • Successfully designed and realized functional XOR and AND logic gates using DNA.
  • Demonstrated the integration of these gates into a half adder logic circuit.
  • Validated the use of ssDNA for signal input and output in DNA computing.

Conclusions:

  • DNA strand displacement reactions can effectively create logic gates for computation.
  • The developed half adder is a foundational step towards complex DNA-based arithmetic circuits.
  • This research offers a potential universal arithmetic tool for DNA molecular programming.