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Clinical experience with ciprofloxacin: analysis of a multicenter study
The Journal of the Kentucky Medical Association
|October 1, 1989
Summary
Ciprofloxacin demonstrated high efficacy in treating various infections, achieving a 100% bacteriologic cure rate and 97.1% clinical cure rate. Adverse reactions were infrequent and mild, with most patients tolerating the antibiotic well.
Area of Science:
- Infectious Diseases
- Pharmacology
- Clinical Medicine
Background:
- Ciprofloxacin is a broad-spectrum fluoroquinolone antibiotic.
- Its efficacy and safety profile require ongoing evaluation across diverse infections.
Purpose of the Study:
- To assess the clinical and bacteriologic outcomes of ciprofloxacin treatment.
- To evaluate the safety and tolerability of ciprofloxacin in a multicenter setting.
Main Methods:
- A multicenter study involving 36 patients with various infections.
- Dosage: mean 986 mg/day; duration: mean 10.8 days.
- Outcomes assessed included microbiologic and clinical cure rates, and adverse events.
Main Results:
- Microbiologic cure/improvement in 100% of 32 microbiologically proven infections.
- Clinical cure/improvement in 97.1% of all 36 infections.
- Adverse reactions reported in 11.1% of patients, with 5.5% discontinuing therapy due to side effects.
Conclusions:
- Ciprofloxacin is highly effective for treating a range of infections.
- The antibiotic exhibits a favorable safety profile with a low incidence of significant adverse events.
