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Real-time Analyses of Retinol Transport by the Membrane Receptor of Plasma Retinol Binding Protein
14:32

Real-time Analyses of Retinol Transport by the Membrane Receptor of Plasma Retinol Binding Protein

Published on: January 28, 2013

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[Association between retinol-binding protein 4 and coronary artery disease in Chinese: a Meta-analysis]

Xiaowen Hou1, Guangxiao Li1, Qiongrui Zhao1

  • 1Department of Clinical Epidemiology and Evidence-based Medicine, Institute of Cardiovascular Diseases, The First Affiliated Hospital, China Medical University, Shenyang 110001, China.

Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi
|January 28, 2016
PubMed

Insights

Retinol-binding protein 4 (RBP4) is associated with coronary artery disease (CAD) in the Chinese population. This finding was consistent across stable angina and acute myocardial infarction subtypes, particularly in younger patients.

Area of Science:

  • Biochemistry
  • Cardiology
  • Epidemiology

Background:

  • Retinol-binding protein 4 (RBP4) is an adipokine linked to metabolic disorders.
  • Its role in coronary artery disease (CAD) among the Chinese population requires clarification.

Purpose of the Study:

  • To evaluate the association between RBP4 levels and CAD in Chinese individuals.
  • To analyze this association across different CAD subtypes and age groups.

Main Methods:

  • A comprehensive literature search was conducted across multiple databases (PubMed, Web of Science, CNKI, etc.) up to February 2015.
  • Included case-control studies were assessed for quality, and data were analyzed using RevMan 5.2 software.
  • A meta-analysis was performed on 10 qualified studies.

Main Results:

  • The pooled analysis of 10 studies revealed a significant association between RBP4 and CAD in Chinese individuals (WMD=7.17 µg/ml, P<0.05).
  • Subgroup analyses indicated RBP4 is associated with both stable angina pectoris (WMD=4.81 µg/ml, P<0.05) and acute myocardial infarction (WMD=13.96 µg/ml, P<0.05).
  • A significant association was observed in patients aged ≤65 years (WMD=7.26 µg/ml, P<0.05).

Conclusions:

  • RBP4 levels are significantly associated with coronary artery disease in the Chinese population.
  • This association is evident in both stable angina and acute myocardial infarction, and particularly in individuals aged 65 years or younger.
Abstract

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