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Updated: Mar 26, 2026
The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury
Published on: October 21, 2017
Evaluation of liver regeneration diet supplemented with omega-3 fatty acids: experimental study in rats
Rosilda Mendes da Silva1, Osvaldo Malafaia1, Orlando Jorge Martins Torres2
1Hospital Universitário Evangélico de Curitiba, Curitiba, PR, Brasil.
Objective:
to evaluate liver regeneration in rats after partial hepatectomy of 60% with and without action diet supplemented with fatty acids through the study of the regenerated liver weight, laboratory parameters of liver function and histological study.
Methods:
thirty-six Wistar rats, males, adults were used, weighing between 195 and 330 g assigned to control and groups. The supplementation group received the diet by gavage and were killed after 24h, 72h and seven days. Evaluation of regeneration occurred through analysis of weight gain liver, serum aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltranspeptidase, and mitosis of the liver stained with H&E.
Results:
the diet supplemented group showed no statistical difference (p>0.05) on the evolution of weights. Administration of fatty acids post-hepatectomy had significant reduction in gamma glutamyltransferase levels and may reflect liver regeneration. Referring to mitotic index, it did not differ between period of times among the groups.
Conclusion:
supplementation with fatty acids in rats undergoing 60% hepatic resection showed no significant interference related to liver regeneration.
