Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serum beta 2-microglobulin levels in thyroid diseases.

H H Lervang1, J Møller-Petersen, J Ditzel

  • 1Department of Medicine, Aalborg Hospital, Denmark.

Journal of Internal Medicine
|October 1, 1989
PubMed
Summary

Serum beta 2-microglobulin levels are elevated in untreated Graves' disease and toxic adenomas, indicating increased metabolism. Levels normalize after treatment, suggesting beta 2-microglobulin as a marker for thyrotoxicosis activity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-Range Transverse-Momentum Correlations and Radial Flow in Pb-Pb Collisions at the LHC.

Physical review letters·2026
Same author

Search for Quasiparticle Scattering in the Quark-Gluon Plasma with Jet Splittings in pp and Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2025
Same author

First Measurement of A=4 Hypernuclei and Antihypernuclei at the LHC.

Physical review letters·2025
Same author

Probing Strangeness Hadronization with Event-by-Event Production of Multistrange Hadrons.

Physical review letters·2025
Same author

Measurements of Chemical Potentials in Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2024
Same author

Observation of Medium-Induced Yield Enhancement and Acoplanarity Broadening of Low-p_{T} Jets from Measurements in pp and Central Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2024

Area of Science:

  • Endocrinology
  • Immunology
  • Clinical Biochemistry

Background:

  • Serum beta 2-microglobulin (S2M) is a protein expressed on the surface of nucleated cells.
  • Its levels can be influenced by cell turnover and immune activation.

Purpose of the Study:

  • To investigate serum beta 2-microglobulin levels in patients with various thyroid diseases.
  • To assess the correlation between S2M levels and thyroid function.

Main Methods:

  • Serum beta 2-microglobulin was measured in 38 patients with thyroid diseases (Graves' disease, toxic adenomas, hypothyroidism) and 60 healthy controls.
  • Statistical analysis, including correlation tests, was performed.

Main Results:

  • Significantly elevated S2M levels were observed in untreated Graves' disease and toxic adenomas compared to controls.

Related Experiment Videos

  • S2M levels decreased significantly after antithyroid treatment, returning to control group levels.
  • No significant difference in S2M levels was found in hypothyroidism patients compared to controls.
  • In untreated hypothyroidism, S2M positively correlated with serum thyroxine (T4) and free thyroxine index (FT4I).

    • Conclusions:

    • Elevated serum beta 2-microglobulin may indicate increased metabolism in thyrotoxicosis.
    • Increased S2M in active Graves' disease could also be linked to immunological activation.