Related Experiment Video
Updated: Mar 26, 2026
08:46
Using Synchrotron Radiation Microtomography to Investigate Multi-scale Three-dimensional Microelectronic Packages
Published on: April 13, 2016
10.6K
Nano-Computed Tomography: Technique and Applications
M Kampschulte1, A C Langheinirch2, J Sender1
1Department of Diagnostic and Interventional Radiology, University Hospital Gießen, Germany.
Rofo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin
|January 28, 2016
Summary
Nano-computed tomography (nano-CT) offers superior sub-micrometer resolution for 3D imaging, advancing beyond micro-CT. This high-resolution technique visualizes cellular-level structures, aiding biomedical research.
Area of Science:
- Radiological imaging
- Biomedical research
- Advanced tomography
Background:
- Nano-computed tomography (nano-CT) is an advancement of micro-CT.
- It utilizes a transmission target X-ray tube for focal spots <400 nm.
- Achieves spatial resolution up to 400 nm (10% MTF).
Purpose of the Study:
- To demonstrate the technical concept and specimen preparation for nano-CT.
- To compare nano-CT with micro-CT for imaging biological structures.
- To highlight the potential of nano-CT in biomedical basic research.
Main Methods:
- Application of transmission target X-ray tube with small focal spot size.
- Utilizing specific detectors and examination protocols for high resolution.
- Exemplary demonstration of nano-CT imaging and specimen preparation.
Main Results:
- Nano-CT achieves superior spatial resolution compared to micro-CT.
- Visualized atherosclerotic plaques (hemorrhage, calcifications) in murine models.
- Demonstrated nano-CT for imaging cerebral microcirculation, lung structures, and trabecular microstructure.
Conclusions:
- Nano-CT provides high-resolution 3D imaging at sub-micrometer levels.
- It enables visualization of cellular-level structures like osteocyte lacunae.
- Represents a significant development in ex-vivo micro-CT technology.
More Related Videos
Related Concept Videos
01:10Computed Tomography
9.5K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
9.5K
01:07Electron Microscope Tomography and Single-particle Reconstruction
3.0K
Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
3.0K
01:25Applications Of NMR In Biology
4.7K
Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
4.7K
01:22Overview of Microscopy Techniques
17.7K
The early pioneers of microscopy opened a window into the invisible world of microorganisms. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes that leveraged nonvisible light, such as fluorescence microscopy that uses an ultraviolet light source and electron microscopy that uses short-wavelength electron beams. These advances significantly improved magnification, image resolution, and contrast. By comparison, the...
17.7K
01:24Magnetic Resonance Imaging
10.3K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
10.3K
01:29Positron Emission Tomography
8.0K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
8.0K