[Anti-N-methyl-D-aspartate receptor encephalitis:clinical analysis of 11 cases]

To analyze the clinical manifestation, laboratory findings, radiological data of anti-N-methyl-D-aspartate (NMDA) receptor encephalitis.

The clinical manifestation, laboratory findings, radiological data of eleven patients with anti-NMDA receptor encephalitis were analyzed.

Main symptoms included epilepsy presented in 9 cases, psychiatric symptom in 7 cases, dyskinesia in 5 cases, autonomic dysfunction in 3 cases. The anti-NMDA receptor antibody was found in all the patients' cerebrospinal fluid (CSF). No teratoma was detected in any of the patients, and 1 case had lung cancer. All the patients received immune therapy. And at discharge, 4 cases recuperated generally, 7 cases had different degrees of dysfunction. After telephone follow-up of 1-18 months, 1 case was lost, 3 cases had complete recovery, and 7 cases had different degrees of sequela.

When Patients without mental illness history presents with unexplained mental symptoms accompanied by seizures, memory impairment, disturbance of consciousness, movement disorders, autonomic dysfunction and other symptoms, anti-NMDA receptor antibodies studies in both serum and CSF should be done as early as possible in order to facilitate early diagnosis, early treatment and improve the prognosis.