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Updated: Mar 26, 2026
In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
Published on: January 2, 2015
Serum cleaved tau protein and traumatic mild head injury: a preliminary study in the Thai population
P Wuthisuthimethawee1, S Saeheng2, T Oearsakul2
1Department of Emergency Medicine, Faculty of Medicine, Songklanagarind Hospital, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand. Prasit0552002@yahoo.com.
Purpose:
To determine the correlation between serum cleaved tau protein and traumatic mild head injury (MHI) (GCS 13-15).
Methods:
A prospective observational study was conducted. Blood specimens from 12 healthy persons and 44 adult patients with traumatic MHI were collected in the emergency department to measure the cleaved tau protein level using a Human Tau phosphoSerine 396 ELISA kit. A brain computed tomography (CT) scan was done in all patients. The serum cleaved tau protein level was considered positive at a cut-off point of 0.1 pg/ml. An intracranial lesion was defined as any abnormality detected by brain CT scan.
Results:
The mean age of the traumatic MHI patients was 34.9 ± 15.6 years (range 15-74). The median GCS was 15. The median time from injury to arrival at the emergency department was 30 min. There were 11 intracranial lesions detected by brain CT scan (25.0 %). Serum cleaved tau protein was not detected in either healthy or traumatic MHI patients.
Conclusion:
As it was uncorrelated with traumatic MHI, serum cleaved tau protein proved to be an unreliable biomarker to use in the early detection of and decision-making for traumatic MHI patients at the emergency department.
