Analysis Treatment Guideline versus Clinical Practice Protocol in Patients Hospitalized due to Heart Failure

Alessandra da Graça Corrêa1, Marcia Makdisse1, Marcelo Katz1

  • 1Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.

Insights

Hospitals showed similar adherence to heart failure medication guidelines. However, a hospital with a case management program had lower in-hospital mortality rates for heart failure patients.

Area of Science:

  • Cardiology
  • Health Services Research
  • Clinical Practice Guidelines

Background:

  • Adherence to established heart failure (HF) treatment guidelines remains suboptimal.
  • Few studies have evaluated hospital-level adherence to recommended HF therapies.

Purpose of the Study:

  • To compare adherence to angiotensin-converting enzyme inhibitor or angiotensin II receptor blockers (ACEI/ARB) and beta-blocker prescriptions at hospital discharge.
  • To evaluate the impact of a hospital case management program (HCP) versus standard treatment guidelines (HCG) on adherence and in-hospital mortality in decompensated HF patients.

Main Methods:

  • Prospective observational study of 1,052 patients with decompensated HF admitted between August 2006 and December 2008.
  • Compared prescription rates of beta-blockers and ACEI/ARB at discharge between HCP and HCG.
  • Assessed in-hospital mortality as a key outcome measure.

Main Results:

  • No significant difference in beta-blocker (69% vs. 69%) or ACEI/ARB (83% vs. 86%) prescription rates at discharge between HCG and HCP.
  • In-hospital mortality was significantly lower at HCP (16.5%) compared to HCG (27.8%).

Conclusions:

  • Hospital-based case management did not improve guideline-directed medication prescribing at discharge for HF patients.
  • Lower in-hospital mortality observed in the case management group may be linked to patient clinical characteristics rather than medication adherence.
  • Further research is needed to understand factors contributing to improved outcomes in case management settings.
Abstract

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