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Analysis Treatment Guideline versus Clinical Practice Protocol in Patients Hospitalized due to Heart Failure
Alessandra da Graça Corrêa1, Marcia Makdisse1, Marcelo Katz1
1Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Insights
Hospitals showed similar adherence to heart failure medication guidelines. However, a hospital with a case management program had lower in-hospital mortality rates for heart failure patients.
Area of Science:
- Cardiology
- Health Services Research
- Clinical Practice Guidelines
Background:
- Adherence to established heart failure (HF) treatment guidelines remains suboptimal.
- Few studies have evaluated hospital-level adherence to recommended HF therapies.
Purpose of the Study:
- To compare adherence to angiotensin-converting enzyme inhibitor or angiotensin II receptor blockers (ACEI/ARB) and beta-blocker prescriptions at hospital discharge.
- To evaluate the impact of a hospital case management program (HCP) versus standard treatment guidelines (HCG) on adherence and in-hospital mortality in decompensated HF patients.
Main Methods:
- Prospective observational study of 1,052 patients with decompensated HF admitted between August 2006 and December 2008.
- Compared prescription rates of beta-blockers and ACEI/ARB at discharge between HCP and HCG.
- Assessed in-hospital mortality as a key outcome measure.
Main Results:
- No significant difference in beta-blocker (69% vs. 69%) or ACEI/ARB (83% vs. 86%) prescription rates at discharge between HCG and HCP.
- In-hospital mortality was significantly lower at HCP (16.5%) compared to HCG (27.8%).
Conclusions:
- Hospital-based case management did not improve guideline-directed medication prescribing at discharge for HF patients.
- Lower in-hospital mortality observed in the case management group may be linked to patient clinical characteristics rather than medication adherence.
- Further research is needed to understand factors contributing to improved outcomes in case management settings.
Background:
Despite the availability of guidelines for treatment of heart failure (HF), only a few studies have assessed how hospitals adhere to the recommended therapies.
Objectives:
Compare the rates of adherence to the prescription of angiotensin-converting enzyme inhibitor or angiotensin II receptor blockers (ACEI/ARB) at hospital discharge, which is considered a quality indicator by the Joint Commission International, and to the prescription of beta-blockers at hospital discharge, which is recommended by national and international guidelines, in a hospital with a case management program to supervise the implementation of a clinical practice protocol (HCP) and another hospital that follows treatment guidelines (HCG).
Methods:
Prospective observational study that evaluated patients consecutively admitted to both hospitals due to decompensated HF between August 1st, 2006, and December 31st, 2008. We used as comparing parameters the prescription rates of beta-blockers and ACEI/ARB at hospital discharge and in-hospital mortality.
Results:
We analyzed 1,052 patients (30% female, mean age 70.6 ± 14.1 years), 381 (36%) of whom were seen at HCG and 781 (64%) at HCP. The prescription rates of beta-blockers at discharge at HCG and HCP were both 69% (p = 0.458), whereas those of ACEI/ARB were 83% and 86%, respectively (p = 0.162). In-hospital mortality rates were 16.5% at HCP and 27.8% at HCG (p < 0.001).
Conclusion:
There was no difference in prescription rates of beta-blocker and ACEI/ARB at hospital discharge between the institutions, but HCP had lower in-hospital mortality. This difference in mortality may be attributed to different clinical characteristics of the patients in both hospitals.
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