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Related Concept Videos

Fractures: Bone Repair01:27

Fractures: Bone Repair

6.6K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
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Biotribological Testing and Analysis of Articular Cartilage Sliding against Metal for Implants
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Bioactive-Coated Implants in Trauma Surgery.

Thomas Fuchs1, Gerhard Schmidmaier2, Michael J Raschke1

  • 1Department of Trauma, Hand, and Reconstructive Surgery, Muenster University Hospital, Muenster, Germany.

European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society
|January 28, 2016
PubMed
Summary
This summary is machine-generated.

Biodegradable coatings on orthopedic implants can deliver growth factors and antibiotics directly to fracture sites, improving healing and preventing infections. This technology shows promise for clinical use in musculoskeletal surgery.

Keywords:
AntibioticsCoatingGrowth factorsImplantsTrauma surgery

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Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Drug Delivery Systems

Background:

  • Musculoskeletal surgery faces complications like delayed healing and infections despite advancements.
  • Current local growth factor applications are limited by cost and quantity requirements.
  • Coated implants offer a solution for localized drug delivery, enhancing therapeutic concentrations and minimizing systemic effects.

Purpose of the Study:

  • To review the efficiency of biodegradable poly(D,L-lactide) coatings for controlled release of active ingredients in orthopedic applications.
  • To demonstrate the potential of coated implants as both stabilization devices and carriers for therapeutic agents.
  • To assess the suitability of this coating technology for clinical translation, including fracture healing and infection prophylaxis.

Main Methods:

  • Review of preclinical models, including fracture healing, intervertebral fusion, and infection models, to evaluate coating efficacy.
  • Analysis of a preliminary clinical study involving gentamicin-coated intramedullary tibial nails in patients with severe soft tissue damage.
  • Evaluation of the poly(D,L-lactide) coating's capacity for controlled release of incorporated growth factors and antibiotics.

Main Results:

  • Preclinical models demonstrated the effectiveness of the coating technology in facilitating local drug release for fracture healing and infection control.
  • A preliminary study indicated the coating's suitability as a key technology for incorporating active ingredients, particularly in revision arthroplasty.
  • Gentamicin-coated nails showed potential, though further investigation is needed for specific fracture types and revision surgeries.

Conclusions:

  • Biodegradable poly(D,L-lactide) implant coatings represent a promising technology for localized delivery of growth factors and antibiotics in musculoskeletal surgery.
  • The coating technology effectively stabilizes fractures while serving as a carrier for therapeutic agents, potentially improving outcomes and reducing complications.
  • Further clinical studies are warranted to fully establish the efficacy of this technology in various orthopedic applications, including complex fractures and revision procedures.