Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

345
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
345
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

315
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
315
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

802
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
802
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

324
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
324
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

335
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
335
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

4.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disentangling urban wastewater sources using isotopic tracers and CEC-based diagnostic indicators.

Environmental research·2026
Same author

Dual use of isotopic and environmental proxy approaches to trace nitrate sources and biogeochemical pathways in an agro-industrially influenced river basin.

The Science of the total environment·2025
Same author

Kinematic Comparison of Different Types of Start Technique in Bi-Finswimming.

Journal of functional morphology and kinesiology·2025
Same author

Hybrid Lanthanide Metal-Organic Compounds with Flavonoids: Magneto-Optical Properties and Biological Activity Profiles.

International journal of molecular sciences·2025
Same author

Code generation in ORCA: progress, efficiency and tight integration.

Physical chemistry chemical physics : PCCP·2024
Same author

Comparison of Ultra-Short Race Pace and High-Intensity Interval Training in Age Group Competitive Swimmers.

Sports (Basel, Switzerland)·2023
Same journal

Re‑fracture risk following implant removal in consolidated hip fractures: a multicenter retrospective cohort study of 575 patients.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2026
Same journal

Physical functionality two years after major trauma: predictors from a single center cohort study.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2026
Same journal

Association between fresh frozen plasma transfusion and mortality stratified by Glasgow Coma Scale scores in isolated traumatic brain injury: a nationwide cohort study in Japan.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2026
Same journal

Percutaneous fixation of posterior pelvic ring lesions in the elderly: current evidence and recent advances.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2026
Same journal

Infrared thermography and dual-layer spectral CT for the detection of femoral vascular compromise: an experimental large animal study.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2026
Same journal

Fixation strategies for periprosthetic femur fractures around knee replacements: a comprehensive single-center analysis of 102 consecutive cases.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2026
See all related articles

Related Experiment Video

Updated: Mar 26, 2026

Evaluating the Function of the Foot Core System in the Elderly
08:25

Evaluating the Function of the Foot Core System in the Elderly

Published on: March 11, 2022

3.4K

Multiple Trauma in Young and Elderly: Are There Any Differences?

Chaim Frizis1,2,2, Anastasios Papadopoulos3, Georgios Akritidis3

  • 11st Surgical Department, "Ippocration" General Hospital of Thessaloniki, Thessaloniki, Greece. georgiosakritidis@hotmail.com.

European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society
|January 28, 2016
PubMed
Summary
This summary is machine-generated.

Elderly trauma patients have similar outcomes to younger patients, indicating age alone does not affect prognosis. Therefore, a unified therapeutic approach is recommended for all multi-trauma patients, regardless of age.

Keywords:
ComorbidityElderlyEmergency operationISSMultiple trauma

More Related Videos

Traditional Trail Making Test Modified into Brand-new Assessment Tools: Digital and Walking Trail Making Test
08:07

Traditional Trail Making Test Modified into Brand-new Assessment Tools: Digital and Walking Trail Making Test

Published on: November 23, 2019

12.0K
Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

7.9K

Related Experiment Videos

Last Updated: Mar 26, 2026

Evaluating the Function of the Foot Core System in the Elderly
08:25

Evaluating the Function of the Foot Core System in the Elderly

Published on: March 11, 2022

3.4K
Traditional Trail Making Test Modified into Brand-new Assessment Tools: Digital and Walking Trail Making Test
08:07

Traditional Trail Making Test Modified into Brand-new Assessment Tools: Digital and Walking Trail Making Test

Published on: November 23, 2019

12.0K
Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

7.9K

Area of Science:

  • Trauma surgery
  • Geriatric medicine
  • Emergency medicine

Background:

  • Old age is a known risk factor, but its impact on the prognosis of injured elderly patients is unclear.
  • Understanding age-related outcomes in trauma is crucial for optimizing patient care.

Purpose of the Study:

  • To investigate the effect of advanced age on the outcomes of elderly patients with multiple traumas.
  • To determine if a distinct therapeutic strategy is necessary for older trauma patients.

Main Methods:

  • Inclusion criteria: patients with at least two injured body regions (AIS grade 4) and an Injury Severity Score (ISS).
  • Comparison between younger (up to 64 years) and elderly (over 65 years) trauma patient groups.
  • Analysis of injury patterns, hemodynamic status, hospitalization, and mortality rates.

Main Results:

  • No significant differences in Injury Severity Score (ISS) or initial hemodynamic status between younger and elderly patients.
  • Elderly patients had a higher rate of intensive care unit (ICU) admission.
  • Overall mortality and mortality in hemodynamically unstable patients were similar between age groups.

Conclusions:

  • Advanced age does not independently influence the final outcome for elderly multi-trauma patients.
  • The therapeutic approach for elderly trauma patients should not differ from that for younger patients.
  • Current treatment protocols are effective for both age groups.