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Updated: Mar 26, 2026

Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex
Published on: July 4, 2018
[Analgesia in intensive care medicine]
J R Ortlepp1, F Luethje2, R Walz3
1Klinik für Innere Medizin und Intensivmedizin, Asklepios Kliniken Schildautal, Karl-Herold-Str. 1, 38723, Seesen, Deutschland. j.ortlepp@asklepios.com.
Accurate pain assessment and management in the intensive care unit (ICU) are crucial. Implementing objective pain classification and combining pharmacological with non-pharmacological approaches improves patient outcomes.
Area of Science:
- Critical Care Medicine
- Pain Management
- Pharmacology
Background:
- Sedative and analgesic administration is standard practice in intensive care units (ICUs).
- Distinguishing between delirium, pain, and anxiety is vital for effective treatment strategies and medication selection.
- Optimal pain therapy and sedation significantly impact patient quality of life and prognosis in the ICU.
Purpose of the Study:
- To present current recommendations for the classification of pain and pain therapy within the ICU setting.
Main Methods:
- A literature search was conducted using PubMed.
- Publications focused on "pain" and "ICU" were identified and reviewed.
Main Results:
- Intensive care patients often experience pain due to numerous procedures and situations.
- Pain perception is influenced by patient orientation, anxiety levels, and sedation depth.
- Analgesics and non-pharmacological interventions effectively reduce patient-perceived stress.
Conclusions:
- Enhancing awareness among healthcare professionals regarding ICU pain triggers and perception is essential.
- Objective classification of pain is necessary for effective management.
- Defining therapeutic targets and consistently integrating non-pharmacological methods alongside appropriate pain medication is recommended.
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