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Development of the Lymphatic System

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...

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Related Experiment Video

Updated: Mar 26, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Pediatric lymphatic malformations: evolving understanding and therapeutic options.

Ann M Defnet¹, Naina Bagrodia¹, Sonia L Hernandez¹

¹Department of Surgery, Section of Pediatric Surgery, Comer Children's Hospital, The University of Chicago Medicine and Biological Sciences, 5839 S. Maryland, Suite A-426, MC 4062, Chicago, IL, 60637, USA.

Pediatric Surgery International

|January 28, 2016

Summary

Treatment for lymphatic malformations is expanding with new therapies. A patient-centered, multidisciplinary approach optimizes quality of life for these complex vascular lesions.

Keywords:

Lymphatic malformation New therapies Sclerotherapy Surgery Treatment

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Area of Science:

Vascular Surgery
Medical Genetics
Pediatric Surgery

Background:

Lymphatic malformations (LMs) are complex congenital vascular anomalies.
Understanding LM biology and genetics is crucial for advancing treatment.
Clinical practice continually informs evolving management strategies.

Purpose of the Study:

To review current and emerging multimodal treatment options for lymphatic malformations.
To emphasize a patient-centered approach guided by multidisciplinary teams.
To highlight the goal of improving quality of life for affected individuals.

Main Methods:

Review of current clinical practices and emerging therapies for lymphatic malformations.
Inclusion of observation, surgical, and minimally invasive treatment modalities.
Discussion of novel medical (sildenafil, propranolol, sirolimus) and surgical (vascularized lymph node transfer) interventions.

Main Results:

A wide range of treatment options are available, from observation to advanced surgical techniques.
Emerging therapies show promise in expanding therapeutic possibilities.
Multidisciplinary care is essential for tailoring treatment to individual patient needs.

Conclusions:

Multimodal treatment for lymphatic malformations is rapidly evolving.
A patient-centered, multidisciplinary approach is key to optimizing outcomes and quality of life.
Continued research is vital for developing more effective clinical pathways for complex lymphatic malformations.