Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Coronary autoregulation.

E O Feigl1

  • 1Department of Physiology and Biophysics, University of Washington, Seattle 98195.

Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
|September 1, 1989
PubMed
Summary

Coronary blood flow autoregulation is primarily driven by local metabolic factors, not myogenic or adenosine mechanisms. Maintaining myocardial oxygen supply and demand balance is crucial for effective coronary autoregulation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alteration of cardiovascular and neuronal function in M1 knockout mice.

Life sciences·2001
Same author

K(ATP)(+) channels, nitric oxide, and adenosine are not required for local metabolic coronary vasodilation.

American journal of physiology. Heart and circulatory physiology·2001
Same author

Feedforward sympathetic coronary vasodilation in exercising dogs.

Journal of applied physiology (Bethesda, Md. : 1985)·2000
Same author

Quantitative analysis of feedforward sympathetic coronary vasodilation in exercising dogs.

Journal of applied physiology (Bethesda, Md. : 1985)·2000
Same author

Role of K(ATP)(+) channels and adenosine in the control of coronary blood flow during exercise.

Journal of applied physiology (Bethesda, Md. : 1985)·2000
Same author

Role of nitric oxide and adenosine in control of coronary blood flow in exercising dogs.

Circulation·2000

Area of Science:

  • Cardiovascular Physiology
  • Cardiac Metabolism
  • Vascular Regulation

Background:

  • Coronary blood flow autoregulation is complex due to the heart's dual role in supplying and receiving its own blood flow.
  • Aortic pressure serves as both perfusion pressure and left ventricular afterload, complicating direct study of coronary autoregulation.
  • Previous studies often isolated the coronary circulation to investigate autoregulation, but this can induce artifacts like the Gregg effect.

Purpose of the Study:

  • To investigate the dominant mechanisms underlying coronary blood flow autoregulation.
  • To determine the role of local metabolism, myogenic responses, and adenosine in maintaining coronary blood flow homeostasis.
  • To elucidate the critical factors influencing effective coronary autoregulation.

Main Methods:

  • Studied coronary autoregulation in cannulated and aorta-perfused coronary circulations.
  • Monitored myocardial metabolism and coronary artery pressure.
  • Assessed coronary venous oxygen tension to evaluate the balance of oxygen supply and demand.

Main Results:

  • Local metabolic vascular control appears to be the primary driver of coronary autoregulation.
  • Enhanced myocardial metabolism leads to autoregulation at higher flow levels.
  • Effective autoregulation is observed when coronary venous oxygen tension is near 20 mmHg.
  • Limited evidence supports a myogenic mechanism or adenosine involvement in coronary autoregulation.

Conclusions:

  • Coronary autoregulation is predominantly mediated by local metabolic mechanisms.
  • The specific substance responsible for metabolic control in coronary autoregulation remains unidentified.
  • The balance between myocardial oxygen supply and demand is essential for proper coronary autoregulation.

Related Experiment Videos