Serum Basic Fibroblastic Growth Factor Levels in Children with Infantile Hemangioma
Hikmet Gulsah Tanyildiz1, Emel Cabi Unal2, Hafize Gokce2
1Division of Pediatric Hematology/Oncology, Cebeci Medical Faculty Ankara, Ankara University, Ankara, Turkey. g_oktay4910@yahoo.com.
Insights
Serum levels of basic fibroblast growth factor (b-FGF) were elevated in infants with hemangioma. However, b-FGF levels did not correlate with disease severity, indicating limited clinical utility for treatment decisions.
Area of Science:
- Pediatric dermatology
- Vascular anomalies
- Biochemistry
Background:
- Infantile hemangioma is a common vascular tumor in infants.
- Basic fibroblast growth factor (b-FGF) is implicated in vascular proliferation.
- Understanding b-FGF's role in hemangioma pathogenesis is crucial.
Purpose of the Study:
- To quantify serum b-FGF levels in young children diagnosed with infantile hemangioma.
- To investigate the correlation between serum b-FGF levels and clinical parameters of hemangioma.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was employed to measure serum b-FGF.
- A cohort of 43 infants with infantile hemangioma was studied.
- Serum b-FGF levels were compared to a healthy control group.
Main Results:
- Serum b-FGF levels were significantly higher in infantile hemangioma patients compared to controls (p < 0.01).
- No statistically significant association was found between serum b-FGF levels and lesion size, number of lesions, or patient age.
Conclusions:
- Basic fibroblast growth factor (b-FGF) plays a significant role in the development of infantile hemangioma.
- Serum b-FGF levels are not a reliable biomarker for predicting treatment necessity in infantile hemangioma.
Objectives:
To determine serum levels of basic fibroblastic growth factor (b-FGF) in hemangioma patients under 2 y of age.
Methods:
The study group consisted of 43 children with infantile hemangioma and b-FGF levels were analyzed using ELISA.
Results:
The serum b-FGF levels were higher in hemangioma patients than in healthy control individuals (p 0.01). There were no differences between the lesion size, number of lesions, patient age and serum b-FGF levels.
Conclusions:
Thus, b-FGF is an important growth factor that plays a central role in hemangioma, but determining b-FGF serum levels was not helpful in distinguishing between patients who require treatment and those who do not.
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