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Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
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Rib stabilization: lessons learned.

M G Gasparri1, W B Tisol2, G B Haasler2

  • 1Division of Thoracic Surgery, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI, 53226, USA. mgasparr@mcw.edu.

European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society
|January 28, 2016
PubMed
Summary
This summary is machine-generated.

Operative rib stabilization for rib fractures and flail chest offers improved outcomes but lacks defined indications. This review discusses the rationale, indications, timing, technique, and postoperative care for this controversial surgical approach.

Keywords:
Chest traumaFlail chestRib fracturesRib stabilization

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Area of Science:

  • Thoracic surgery
  • Trauma surgery
  • Surgical innovation

Background:

  • Management of rib fractures and flail chest has evolved over the past century.
  • Renewed interest in operative rib stabilization for these injuries.
  • Existing reports suggest improved outcomes, but indications and approach remain controversial.

Purpose of the Study:

  • To provide expert opinion on operative rib stabilization for rib fractures and flail chest.
  • To discuss the rationale, indications, timing, technique, and postoperative care.
  • To contribute to the ongoing debate on surgical management of these injuries.

Main Methods:

  • Retrospective review of personal experience.
  • Analysis of over 100 patients undergoing rib stabilization.
  • Expert opinion and discussion based on clinical experience.

Main Results:

  • The authors offer their opinions on the procedure.
  • Discussion covers key aspects from rationale to postoperative care.
  • Highlights the need for well-defined indications and standardized approach.

Conclusions:

  • Operative rib stabilization is a viable option for select patients with rib fractures and flail chest.
  • Further research and consensus are needed to define clear indications and optimize surgical techniques.
  • Personal experience suggests benefits, but the approach requires careful consideration of patient factors and surgical expertise.