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Association between thyroid dysfunction and venous thromboembolism in the elderly: a prospective cohort study.
D Segna1, M Méan1,2, A Limacher3
1Department of General Internal Medicine, Bern University Hospital and University of Bern, Bern, Switzerland.
Journal of Thrombosis and Haemostasis : JTH
|January 28, 2016
Summary
Subclinical hyperthyroidism (SHyper) may lower recurrent venous thromboembolism (rVTE) risk in elderly patients. Subclinical hypothyroidism (SHypo) showed a trend toward increased rVTE risk but no significant association with mortality.
Area of Science:
- Geriatric Medicine
- Endocrinology
- Cardiovascular Medicine
Background:
- Subclinical thyroid dysfunction (SCTD) is common in elderly patients and linked to increased thromboembolic risk.
- Prospective data on SCTD and venous thromboembolism (VTE) recurrence are limited.
Purpose of the Study:
- To investigate the association between SCTD and recurrent VTE (rVTE) in elderly patients.
- To assess the relationship between SCTD, all-cause mortality, and thrombophilic biomarkers.
Main Methods:
- Prospective multicenter cohort study of 561 elderly VTE patients.
- Thyroid hormones and thrombophilic biomarkers measured 1 year post-VTE.
- Defined subclinical hypothyroidism (SHypo) and subclinical hyperthyroidism (SHyper) based on TSH levels.
Main Results:
- SHypo (6%) and SHyper (5%) were observed in elderly VTE patients.
- SHyper was associated with a reduced risk of rVTE (sub-hazard ratio 0.00).
- SHypo showed a non-significant trend toward increased rVTE risk (sub-hazard ratio 1.50).
Conclusions:
- SHyper may be linked to a lower risk of recurrent VTE in elderly individuals.
- SHypo did not show a statistically significant association with increased rVTE or mortality.
- No differences in thrombophilic biomarkers were found between SCTD and euthyroid groups.
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