CUG-binding protein 1 (CUGBP1) expression and prognosis of brain metastases from non-small cell lung cancer
Xiaofei Wang1, Wenjie Jiao1, Yandong Zhao1
1Department of Thoracic Surgery The Affiliated Hospital of Qingdao University Qingdao China.
Background:
The brain is a frequent site of metastases from non-small cell lung cancer (NSCLC). The purpose of this study was to detect the expression of CUG-binding protein 1 (CUGBP1) messenger ribonucleic acid (mRNA) and Ki-67 in metastasized brain tissue from NSCLC and determine the relationship between CUGBP1 and brain metastases.
Methods:
The expression of CUGBP1 mRNA and Ki-67 in metastasized brain tissue from NSCLC was investigated by semiquantitative polymerase chain reaction and immunohistochemistry, respectively. The expression of CUGBP1 and Ki-67 in metastasized brain tissue from NSCLC was related to clinical characteristics, as assessed using the chi-square test. The prognostic significance was assessed by univariate and multivariate analyses using the Cox hazard model.
Results:
The expression of CUGBP1 mRNA and Ki-67 was overexpressed in metastasized brain tissue from NSCLC and was correlated with differentiation. In addition, by both univariate and multivariate survival analyses, CUGBP1 expression, Ki-67 expression, and age were noted to be independent indicators of a shorter postsurgical survival.
Conclusion:
The expression of CUGBP1 is an important factor in the development of brain metastases from NSCLC.
