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Modified-Release Drug Delivery Systems: Stimuli-Activated

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Multi-responsive hydrogels for drug delivery and tissue engineering applications.

Jennifer M Knipe¹, Nicholas A Peppas¹

¹Department of Chemical Engineering, C0400, The University of Texas at Austin, Austin, TX 78712, USA, Department of Biomedical Engineering, C0800, The University of Texas at Austin, Austin, TX 78712, USA, College of Pharmacy, C0400, The University of Texas at Austin, Austin, TX 78712, USA.

Regenerative Biomaterials

|January 28, 2016

Summary

This summary is machine-generated.

Intelligent hydrogels respond to multiple stimuli, offering advanced biomaterials for drug delivery and tissue engineering. Recent developments focus on various network types and their regenerative applications.

Keywords:

drug delivery hydrogels intelligent polymers regenerative medicine

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Area of Science:

Biomaterials Science
Regenerative Medicine
Polymer Chemistry

Background:

Multi-responsive hydrogels, or 'intelligent' hydrogels, are biocompatible materials responding to diverse stimuli.
These materials exhibit tunable, controllable, and biomimetic properties, making them valuable for advanced applications.

Purpose of the Study:

To review recent advancements in multi-responsive hydrogel networks.
To discuss challenges and applications in drug delivery and tissue engineering.

Main Methods:

Exploration of supramolecular hydrogel networks.
Analysis of layer-by-layer assembled hydrogel networks.
Investigation of covalently cross-linked multi-responsive hydrogel networks.

Main Results:

Multi-responsive hydrogels show significant utility as regenerative biomaterials.
These hydrogels provide specific responses to physiological or external stimuli.
Tunable and biomimetic behaviors are key attributes for their applications.

Conclusions:

Multi-responsive hydrogels are promising for drug delivery and tissue engineering.
Further research into different network architectures is ongoing.
Addressing challenges will enhance their clinical translation.