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Updated: Mar 26, 2026
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
Multi-responsive hydrogels for drug delivery and tissue engineering applications
Jennifer M Knipe1, Nicholas A Peppas1
1Department of Chemical Engineering, C0400, The University of Texas at Austin, Austin, TX 78712, USA, Department of Biomedical Engineering, C0800, The University of Texas at Austin, Austin, TX 78712, USA, College of Pharmacy, C0400, The University of Texas at Austin, Austin, TX 78712, USA.
Abstract:
Multi-responsive hydrogels, or 'intelligent' hydrogels that respond to more than one environmental stimulus, have demonstrated great utility as a regenerative biomaterial in recent years. They are structured biocompatible materials that provide specific and distinct responses to varied physiological or externally applied stimuli. As evidenced by a burgeoning number of investigators, multi-responsive hydrogels are endowed with tunable, controllable and even biomimetic behavior well-suited for drug delivery and tissue engineering or regenerative growth applications. This article encompasses recent developments and challenges regarding supramolecular, layer-by-layer assembled and covalently cross-linked multi-responsive hydrogel networks and their application to drug delivery and tissue engineering.
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