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Valproate Induced Hyperammonemic Delirium
Anupama Muraleedharan1, Dhanya Sasidharan Palappallil2, Reneega Gangadhar3
1Junior Resident, Department of Pharmacology, Government TDMC , Alappuzha, Kerala, India .
Abstract:
Sodium valproate induced hyperammonaemic delirium with normal liver function tests is a relatively uncommon adverse effect. It may be mistaken for psychosis or worsening of mania leading to wrong diagnosis and improper management. Plasma ammonia levels should be monitored in all patients developing altered mental status after receiving valproate therapy. This is a case series of hyperammonaemic delirium due to valproate reported to the Department of Pharmacology from Department of Psychiatry over a period of one year.
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