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Published on: January 31, 2018
Evaluation of Endothelial and Platelet Derived Microparticles in Patients with Acute Coronary Syndrome
Melvin George1, M R Ganesh2, Aruna Sridhar3
1Assistant Professor, Department of Cardiology, SRM Medical College Hospital & Research Centre , Tamil Nadu, India .
Background:
Microparticles (MP) are a nuclear fragments of membrane released by the damaged cell during stress. Elevated levels of MP have been found in patients with acute coronary syndrome (ACS) owing to the damage in the endothelium.
Aim:
To determine if the levels of endothelial and platelet microparticles (EMP & PMP) in patients with ACS influenced the severity of the disease.
Materials And Methods:
This was a prospective cohort study performed in 63 ACS patients (ST elevation myocardial infarction- STEMI-28, non ST elevation myocardial infarction -NSTEMI-35). After obtaining consent, blood samples were collected from the patients and processed by flow cytometry.
Results:
The NSTEMI group had higher levels of EMP {792.11(327.59-1661.49) vs 300.35 (176.3-550.46), p=0.001} and PMP {218.87(86.65-439.77) vs 114.45(50.34-196.75), p= 0.007} as compared to the STEMI group. However, it was found that the EMP (r=-0.438, p=0.001) and PMP (r= -0.316, p=0.024) negatively correlated with Global Registry of Acute Coronary Events score (GRACE in-hospital score) for the entire cohort.
Conclusion:
The levels of microparticles are elevated in ACS patients and may reflect a protective effect in patients with acute coronary syndrome.
Insights
Elevated endothelial and platelet microparticles were found in acute coronary syndrome patients. Higher levels in non-STEMI patients correlated negatively with disease severity, suggesting a potential protective role.
Area of Science:
- Cardiovascular Medicine
- Biomarkers
- Cellular Biology
Background:
- Microparticles (MP) are membrane fragments released by stressed cells.
- Elevated MP levels are observed in acute coronary syndrome (ACS) due to endothelial damage.
Purpose of the Study:
- To investigate the relationship between endothelial microparticles (EMP) and platelet microparticles (PMP) levels and ACS severity.
- To determine if EMP and PMP influence disease severity in ACS patients.
Main Methods:
- Prospective cohort study of 63 ACS patients (28 STEMI, 35 NSTEMI).
- Blood samples analyzed using flow cytometry.
- Correlation analysis with Global Registry of Acute Coronary Events (GRACE) score.
Main Results:
- NSTEMI patients exhibited significantly higher EMP and PMP levels compared to STEMI patients.
- Both EMP and PMP showed a negative correlation with the GRACE in-hospital score in the overall ACS cohort.
- EMP (r=-0.438, p=0.001) and PMP (r=-0.316, p=0.024) negatively correlated with disease severity.
Conclusions:
- Microparticle levels are elevated in ACS patients.
- Higher EMP and PMP levels may indicate a protective effect in ACS.
- These findings highlight the potential role of microparticles as biomarkers in ACS.
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