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[Impact of male reproductive tract infection on semen quality]

Yong-gen Wu, Xu Yang, Huan Zhang

    Zhonghua Nan Ke Xue = National Journal of Andrology
    |January 29, 2016
    PubMed
    Abstract

    Insights

    Male reproductive tract infections (RTI) negatively impact semen quality and sperm DNA integrity. This study found RTIs are associated with reduced semen volume, lower normal sperm morphology, and significantly increased sperm DNA fragmentation.

    Area of Science:

    • Reproductive Biology
    • Andrology
    • Infectious Diseases

    Background:

    • Male reproductive tract infections (RTI) are a potential cause of male infertility.
    • Assessing the impact of RTI on semen parameters and sperm DNA damage is crucial for understanding male reproductive health.

    Purpose of the Study:

    • To investigate the association between male reproductive tract infection (RTI) and semen parameters.
    • To evaluate the impact of RTI on sperm DNA damage.

    Main Methods:

    • 1,084 males were classified into an RTI group (n=300) and a non-RTI control group (n=784).
    • Routine semen parameters and sperm morphology were assessed according to WHO standards.
    • Sperm DNA fragmentation index (DFI) was determined using the sperm chromatin structure assay.

    Main Results:

    • The RTI group showed statistically significant differences in semen volume, sperm motility (grades a+b), abnormal sperm (grade d), and total sperm count compared to the control group.
    • Males with RTI had a significantly lower percentage of morphologically normal sperm and a markedly higher DFI.
    • Elevated seminal plasma elastase levels in the RTI group correlated with reduced sperm quality and increased DNA damage.

    Conclusions:

    • Male reproductive tract infection adversely affects key semen parameters and sperm morphology.
    • RTI is strongly associated with significant sperm DNA damage, highlighting its detrimental effect on male fertility.

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