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Prostaglandin secretion by the blastocyst
1Beltsville Agricultural Research Center, Livestock and Poultry Sciences Institute, Maryland 20705.
Abstract:
Conceptuses from some mammals synthesized prostaglandins (PG) in vitro. Blastocysts from cattle produced primarily PGF-2 alpha; those from sheep produced mainly 6-keto-PGF-1 alpha and PGF-2 alpha; and those from pigs produced mostly PGE-2. Rabbits have not been shown to produce a predominant PG and mice and rats have not been shown to produce detectable amounts of PG. Other species do not appear to have been studied. Prostaglandins of conceptus origin appear to be involved directly in: intrauterine migration of embryos; blastocyst hatching from the zona pellucida; ion transport across trophectoderm; fluid accumulation in the blastocoele; increased endometrial capillary permeability; blastocystic glucose metabolism.