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Updated: Mar 26, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
A patient with Factor V Leiden and a related pulmonary embolism
Janet Downs1, William A Childers
1Janet Downs practices emergency medicine at Genesis Healthcare in Zanesville, Ohio. William A. Childers, Jr., is director of the PA program at West Liberty (W.Va.) University. The authors have disclosed no potential conflicts of interest, financial or otherwise.
Abstract:
Venous thromboembolism (VTE) is a complication associated with the hypercoaguable state produced in patients with Factor V Leiden deficiency. Clinically, patients can present with pleuritic chest pain, dyspnea, tachycardia, and unilateral leg swelling, warmth, erythema, and pain. Treatment with heparin is urgent, and patients should continue an anticoagulation drug regimen at home.
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