Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antibiotic Selection00:57

Antibiotic Selection

62.0K
Overview
62.0K
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

1.9K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.9K
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

69
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
69
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

26
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
26
Genomic DNA in Prokaryotes00:46

Genomic DNA in Prokaryotes

50.5K
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
50.5K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.9K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular epidemiology of community-acquired MRSA (CA-MRSA) and hospital-acquired MRSA (HA-MRSA): sequence types, virulence profiles, and antimicrobial resistance in a Belgian hospital network.

Infection·2026
Same author

How can biological databases support the new UN mechanism for benefit-sharing from digital sequence information?

Scientific data·2026
Same author

Urosepsis by multidrug-resistant <i>Nakaseomyces glabratus</i> with non-functional Erg3 and Erg11-do collateral sensitivity and a unique mode of action make nitroxoline a viable UTI antifungal?

mBio·2026
Same author

The role of whole genome sequencing in antimicrobial susceptibility prediction of bacteria: 2025 update from the European Committee on Antimicrobial Susceptibility Testing Subcommittee.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2026
Same author

Reinfection and ceftriaxone tolerance in a clinical case of recurrent gonorrhoea: a case report supported by <i>in vitro</i> and <i>in vivo</i> models.

Frontiers in cellular and infection microbiology·2026
Same author

Characterizing ceftriaxone tolerance in <i>Neisseria gonorrhoeae</i> across <i>in vitro</i> and <i>in vivo</i> models.

mSystems·2026

Related Experiment Video

Updated: Mar 26, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

8.3K

Consolidating and Exploring Antibiotic Resistance Gene Data Resources.

Basil Britto Xavier1, Anupam J Das1, Guy Cochrane2

  • 1Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute, Universiteit Antwerpen, Antwerp, Belgium.

Journal of Clinical Microbiology
|January 29, 2016
PubMed
Summary

Antibiotic resistance (AR) and multidrug-resistant (MDR) bacteria spread rapidly. This study reviews current AR gene databases, highlighting limitations and proposing solutions for better researcher access to vital antimicrobial resistance data.

More Related Videos

Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

11.8K
Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
09:00

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance

Published on: May 2, 2018

12.5K

Related Experiment Videos

Last Updated: Mar 26, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

8.3K
Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

11.8K
Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
09:00

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance

Published on: May 2, 2018

12.5K

Area of Science:

  • Microbiology
  • Genomics
  • Bioinformatics

Background:

  • Unrestricted antibiotic use drives rapid acquisition of antibiotic resistance (AR) and spread of multidrug-resistant (MDR) bacterial pathogens.
  • Next-generation sequencing technologies offer insights into MDR pathogen dynamics.
  • Existing AR gene data resources are fragmented, leading to inconsistencies and inaccuracies.

Purpose of the Study:

  • To enhance the visibility of existing AR gene data resources for the clinical microbiology community.
  • To identify limitations in current AR gene databases.
  • To propose solutions for a unified and accessible AR gene data platform.

Main Methods:

  • Literature review of existing antibiotic resistance gene databases.
  • Analysis of data availability, consistency, and accuracy across different resources.
  • Identification of gaps and challenges in current data resource management.

Main Results:

  • Current AR gene databases lack a centralized platform, resulting in variable data quality.
  • Information accessibility, consistency, and accuracy are significant issues across disparate resources.
  • Limited visibility hinders effective utilization by the clinical microbiology community.

Conclusions:

  • A unified platform for AR gene data is crucial for advancing research on antibiotic resistance.
  • Addressing the limitations of current databases will improve data accessibility and reliability.
  • Enhanced visibility and standardization of AR gene resources are essential for combating MDR pathogens.