Related Experiment Video
Updated: Mar 26, 2026

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
Published on: July 28, 2022
Protein-losing enteropathy and erythema caused by egg allergy in a breast-fed infant
Ryuzo Higuchi1, Mina Booka1, Hiroyuki Suzuki1
1Department of Pediatrics, Wakayama Medical University.
Insights
In infants, food allergies like egg allergy can cause protein-losing enteropathy (PLE), leading to poor weight gain and edema. Dietary changes and medication can effectively treat these conditions.
Area of Science:
- Pediatric Gastroenterology
- Clinical Immunology
- Allergy Research
Background:
- Protein-losing enteropathy (PLE) in infants presents with poor weight gain, edema, and hypoalbuminemia.
- The role of IgE-mediated food allergy in infant PLE is not fully understood.
- This case highlights a potential link between food allergy and PLE in a breast-fed infant.
Abstract:
A 4-month-old breast-fed girl presented with poor weight gain, and had edema and repeated erythema from 5 months of age. The diagnosis of protein-losing enteropathy (PLE) was confirmed on 99m Tc-labeled human serum albumin scintigraphy. Specific IgE radioallergosorbent test was class 3 for egg white, class 2 for egg yolk, and negative for other foods. Elimination of egg from the mother's diet and oral epinastine hydrochloride treatment and sodium cromolyn improved hypoalbuminemia, hypogammaglobulinemia, and erythema. PLE and erythema coincident in a breast-fed infant suggests that IgE-mediated allergy may play a leading role in some cases of PLE due to food allergy in infants.
More Related Videos
Related Concept Videos
Inborn Errors of Metabolism
Overview of Protein Metabolism
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Nephrotic Syndrome I : Introduction
Drug Toxicity: Allergic Reactions
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

