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Updated: Mar 26, 2026
The Use of Gas Chromatography to Analyze Compositional Changes of Fatty Acids in Rat Liver Tissue during Pregnancy
Published on: March 13, 2014
Frequency of intrahepatic cholestasis of pregnancy in Punjab Pakistan: A single centre study
Muhammad Hafeez1, Asma Ansari2, Saima Parveen3
1Department of Medicine, Gastroenterology, CMH, Kharian Cantt.
Objective:
To find out the frequency of intrahepatic cholestasis of pregnancy and its identification parameters.
Methods:
The cross-sectional observational study was conducted in the Department of Medicine and the Department of Obstetrics, Combined Military Hospital, Kharian, from October 2013 to March 2014, and comprised all pregnant patients having symptoms suggestive of intrahepatic cholestasis which was confirmed after systemic inquiry, examination and biochemical analysis. Patients with cholestasis due to another reason, coagulopathies, thrombocytopenia and tumours were excluded. The patients were followed up till delivery to see the effects of cholestasis on mother and child.
Results:
Out of 1001 obstetric patients, 31(3.1%) had intrahepatic cholestasis of pregnancy. Pruritus was the main symptom in 25 (85%) patients followed by rash in 20 (65%). In 20 (64%) patients, labour was induced. Mode of delivery was Caesarean Section in 18 (58%) patients and 9 (29%) had postpartum haemorrhage. Regarding neonatal complications, 22 (70%) required admission to neonatal intensive care and 15 (48%) had meconium aspiration.
Conclusions:
A high frequency of intrahepatic cholestasis of pregnancy was observed. It had significant impact on maternal and foetal health.
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