Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Body mass index and achievement of minimal disease activity in psoriatic arthritis across different classes of advanced therapy.

Rheumatology (Oxford, England)·2026
Same author

SREBPs in Metabolic Reprogramming and Disease: Mechanisms and Therapeutic Potential.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

Tetrahedral Framework Nucleic Acids Re-establish Immune Tolerance and Restore Thyroid Function in Hashimoto's Thyroiditis via NOTCH1 Signaling Pathway Inhibition.

ACS applied materials & interfaces·2026
Same author

Integrating molecular dynamics and experimental validation reveals ShenQi granule stabilizes podocyte cytoskeleton by modulating Bax/Bcl2-caspase-3 rheostat in IMN.

Journal of ethnopharmacology·2026
Same author

A hybrid-frequency programmable synthetic-dimension simulator with rich coupling on a single chip.

Light, science & applications·2026
Same author

Associations of mortality with leisure-time physical activity and sitting time in postmenopausal women: Insights from NHANES.

Maturitas·2026
Same journal

Effect of Endoscopic Retrograde Appendicitis Therapy on Postoperative Gastrointestinal Function in Patients With Chronic Fecalith Appendicitis.

Gastroenterology research and practice·2026
Same journal

Divergent Trajectories of the Burden of MASLD Attributable to High Fasting Plasma Glucose in China and Globally: A GBD Study 1990-2021 and Projections to 2046.

Gastroenterology research and practice·2026
Same journal

From "Monarch, Minister, Assistant, and Envoy" to "Microbial Dialogue": A Review of Novel Mechanisms by Which Chinese Herb Pairs Improve Metabolic Diseases Through Gut Microbiota Metabolic Regulation.

Gastroenterology research and practice·2026
Same journal

Effects of Aging on Correlation of Striated Esophageal and Pharyngeal Deglutitive Motor Function.

Gastroenterology research and practice·2026
Same journal

RETRACTION: "Influence of Rosiglitazone on the Expression of PPAR<i>γ</i>, NF-<i>κ</i>B,and TNF-<i>α</i> in Rat Model of Ulcerative Colitis".

Gastroenterology research and practice·2026
Same journal

High Prevalence of Sarcopenia in Noncirrhotic Women With Primary Biliary Cholangitis: A Comparative Study of Clinical Characteristics and Risk Factors.

Gastroenterology research and practice·2026
See all related articles

Related Experiment Video

Updated: Mar 26, 2026

Murine Model of Intestinal Ischemia-reperfusion Injury
07:07

Murine Model of Intestinal Ischemia-reperfusion Injury

Published on: May 11, 2016

20.9K

Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion Model.

Mu Yang1, Jian-Xin Dong1, Lu-Bin Li1

  • 1Department of Vascular Surgery, Yantai Yuhuangding Hospital, The Affiliated Hospital of Medical College, Qingdao University, Yantai 264000, China.

Gastroenterology Research and Practice
|January 29, 2016
PubMed
Summary
This summary is machine-generated.

Local and remote ischemia postconditioning protect against intestinal injury. Both methods were equally effective in reducing oxidative stress, neutrophil activation, and apoptosis in a rabbit model.

More Related Videos

Rodent Model of Intestinal Ischemia-Reperfusion Injury via Occlusion of the Superior Mesenteric Artery
06:29

Rodent Model of Intestinal Ischemia-Reperfusion Injury via Occlusion of the Superior Mesenteric Artery

Published on: October 20, 2023

2.6K
Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia
08:55

Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia

Published on: May 18, 2018

11.4K

Related Experiment Videos

Last Updated: Mar 26, 2026

Murine Model of Intestinal Ischemia-reperfusion Injury
07:07

Murine Model of Intestinal Ischemia-reperfusion Injury

Published on: May 11, 2016

20.9K
Rodent Model of Intestinal Ischemia-Reperfusion Injury via Occlusion of the Superior Mesenteric Artery
06:29

Rodent Model of Intestinal Ischemia-Reperfusion Injury via Occlusion of the Superior Mesenteric Artery

Published on: October 20, 2023

2.6K
Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia
08:55

Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia

Published on: May 18, 2018

11.4K

Area of Science:

  • Gastroenterology
  • Surgical Research
  • Pathophysiology

Background:

  • Intestinal ischemia/reperfusion (I/R) injury is a critical condition with substantial morbidity and mortality.
  • Postconditioning protocols offer a potential therapeutic strategy to mitigate I/R injury.
  • Understanding the efficacy of different postconditioning approaches is crucial for clinical application.

Purpose of the Study:

  • To investigate the protective effects of local ischemia postconditioning (LIPo) and remote ischemia postconditioning (RIPo) on intestinal I/R injury.
  • To compare the efficacy of LIPo and RIPo in ameliorating the pathological consequences of intestinal I/R.
  • To elucidate the underlying mechanisms, including oxidative stress, neutrophil activation, and apoptosis, modulated by these interventions.

Main Methods:

  • Establishment of a rabbit model for intestinal ischemia/reperfusion (I/R) injury.
  • Application of local ischemia postconditioning (LIPo) and remote ischemia postconditioning (RIPo) protocols.
  • Assessment of key injury markers, including oxidative stress, neutrophil activation, and apoptosis.

Main Results:

  • Both LIPo and RIPo demonstrated significant protective effects against intestinal I/R injury.
  • The protective efficacy of LIPo was comparable to that of RIPo.
  • Postconditioning interventions led to a reduction in oxidative stress, neutrophil activation, and apoptosis.

Conclusions:

  • Local ischemia postconditioning (LIPo) provides significant protection against intestinal I/R injury.
  • Remote ischemia postconditioning (RIPo) offers comparable protection to LIPo.
  • Both LIPo and RIPo attenuate intestinal I/R injury by reducing oxidative stress, neutrophil activation, and apoptosis.