Related Experiment Video
Updated: Mar 26, 2026
28:15
Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
Published on: July 28, 2010
12.8K
Colorectal Carcinogenesis, Radiation Quality, and the Ubiquitin-Proteasome Pathway
Kamal Datta1, Shubhankar Suman1, Santosh Kumar1
11. Department of Biochemistry and Molecular & Cellular Biology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC USA.
Journal of Cancer
|January 29, 2016
Summary
Radiation exposure can disrupt colorectal cancer development by altering Wnt/β-catenin signaling and the ubiquitin-proteasome pathway (UPP). This review explores how radiation quality impacts these pathways in colorectal cancer initiation and progression.
Area of Science:
- Oncology
- Molecular Biology
- Radiation Biology
Background:
- Adult colorectal epithelium relies on regulated cellular processes for homeostasis.
- The Wnt/β-catenin pathway is crucial for colorectal development and maintenance.
- Deregulated Wnt/β-catenin signaling is a key factor in colorectal carcinogenesis.
Purpose of the Study:
- To review recent advancements in understanding colorectal carcinogenesis.
- To explore the role of radiation exposure in deregulating Wnt/β-catenin signaling.
- To investigate the impact of radiation quality on the ubiquitin-proteasome pathway (UPP) in colorectal cancer.
Main Methods:
- Literature review of studies on radiation exposure and colorectal cancer.
- Analysis of the effects of different radiation types and qualities on signaling pathways.
- Examination of the ubiquitin-proteasome pathway's role in radiation-induced carcinogenesis.
Main Results:
- Radiation exposure is linked to colorectal carcinogenesis.
- Radiation alters Wnt/β-catenin signaling and the UPP.
- Radiation quality influences the deregulation of these pathways.
Conclusions:
- Radiation significantly impacts colorectal cancer initiation and progression.
- Understanding radiation's effects on Wnt/β-catenin and UPP is crucial.
- Further research into radiation quality's role can inform cancer prevention and treatment strategies.
Keywords:
APCMin/+HZE-particlesHigh-LET radiationIntestinal tumorProteasomeSpace radiationTumorigenesisβ-cateninMore Related Videos
Related Concept Videos
01:25Mutagenicity and Carcinogenicity
2.1K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
2.1K
01:38Nucleotide Excision Repair
5.7K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
5.7K
01:08Nucleotide Excision Repair
41.9K
Overview
41.9K
02:07Tumor Progression
7.8K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.8K
02:04Covalently Linked Protein Regulators
9.9K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
These groups modify specific amino acids in a protein....
9.9K
01:13The Proteasome
2.0K
Eukaryotic cells can degrade proteins through several pathways. One of the most important among these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. This involves participation of a series of enzymes including— E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. This involves participation of a series of enzymes including— E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
2.0K