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Primary Intracranial Leptomeningeal Melanomatosis
Do-Hyoung Kim1, Chan-Young Choi1, Chae-Heuck Lee1
1Department of Neurosurgery, Ilsan Paik Hospital, College of Medicine, Inje University, Goyang, Korea.
Abstract:
Primary intracranial malignant melanoma is a very rare and highly aggressive tumor with poor prognosis. A 66-year-old female patient presented a headache that had been slowly progressing for several months. A large benign pigmented skin lesion was found on her back. A brain MRI showed multiple linear signal changes with branching pattern and strong enhancement in the temporal lobe. The cytological and immunohiostochemical cerebrospinal fluid examination confirmed malignant melanoma. A biopsy confirmed that the pigmented skin lesion on the back and the conjunctiva were benign nevi. We report a case of primary intracranial malignant melanoma and review relevant literatures.
Insights
This case report details a rare primary intracranial malignant melanoma in a 66-year-old female. Despite a benign skin nevus, brain imaging and cerebrospinal fluid analysis confirmed the aggressive brain tumor.
Area of Science:
- Neuro-oncology
- Dermatopathology
- Ophthalmology
Background:
- Primary intracranial malignant melanoma is an exceptionally rare and aggressive brain tumor.
- It presents a significant diagnostic challenge due to its rarity and potential for misdiagnosis.
- Patients often exhibit poor prognosis, necessitating early and accurate diagnosis.
