Angioedema-Urticaria Due to Acitretin.

Area of Science:

• Dermatology
• Pharmacology

Background:

• Acitretin is a synthetic oral retinoid used for dermatological conditions.
• Known side effects include teratogenicity, cheilitis, xerosis, dyslipidemia, and photosensitivity.
• Drug-induced angioedema-urticaria is often associated with antibiotics and NSAIDs.

Observation:

• A case study of a 61-year-old male patient with psoriasis is presented.
• The patient developed angioedema-urticaria.
• The reaction was confirmed via an oral provocation test with acitretin.

Findings:

• This report details a rare instance of angioedema-urticaria induced by oral acitretin.
• Only one prior case of acitretin-induced angioedema has been documented in medical literature.
• The oral provocation test confirmed acitretin as the causative agent.

Implications:

• This case underscores that acitretin may induce angioedema-urticaria, a side effect not commonly associated with this drug.
• Healthcare providers should be aware of this potential adverse reaction when prescribing acitretin.
• Patients should be informed about the risk of angioedema-urticaria alongside other known side effects of acitretin.