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The Bovine Lung in Biomedical Research: Visually Guided Bronchoscopy, Intrabronchial Inoculation and In Vivo Sampling Techniques

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Genetically engineered livestock for biomedical models.

Christopher S Rogers¹

¹Exemplar Genetics, 2500 Crosspark Rd., Ste E126, Coralville, IA, 52241, USA. chris.rogers@exemplargenetics.com.

Transgenic Research

|January 29, 2016

Summary

This summary is machine-generated.

Genetically engineered livestock are now advanced biomedical models, significantly improving disease research since 1997. Key developments include transgenic disease models and cloning, overcoming previous limitations in animal research.

Keywords:

Animal model Caprine Genetically engineered Human disease Livestock Ovine Porcine

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Area of Science:

Biomedical research
Genetically engineered animals
Livestock models

Background:

The field of transgenic animal research has advanced significantly since 1997.
Early research relied on wild-type or naturally occurring disease models.
The development of transgenic livestock models was a major breakthrough.

Purpose of the Study:

To review progress in developing genetically engineered livestock as biomedical models.
To highlight key achievements in transgenic livestock model development.
To discuss current challenges in utilizing these advanced models.

Main Methods:

Review of scientific literature and conference proceedings.
Focus on advancements since the watershed year of 1997.
Emphasis on the role of cloning and somatic cell nuclear transfer.

Main Results:

Development of the first transgenic livestock disease model (pig with retinitis pigmentosa).
Cloning became integral to creating most livestock disease models.
Significant progress in overcoming technical hurdles for model development.

Conclusions:

Genetically engineered livestock represent powerful biomedical models.
The field has overcome many technical challenges in model creation.
Practical application and utilization of these models present new challenges.