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Ramping up degradation for proliferation
Jon M Huibregtse1, Andreas Matouschek1
1Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas 78712, USA.
Nature Cell Biology
|January 29, 2016
Abstract:
The control of proteasome-mediated protein degradation is thought to occur mainly at the level of polyubiquitylation of the substrate. However, the proteasome can also be regulated directly, as now demonstrated by a study in which DYRK2-mediated phosphorylation of the 19S subunit Rpt3 is found to increase proteasome activity.