Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastrulation01:56

Gastrulation

68.9K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
68.9K
Embryonic Connective Tissues01:20

Embryonic Connective Tissues

7.2K
During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development.
7.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retinoic acid regulates fetoplacental vascularization via notch signaling and a SEMA3E/F-PLEXIND1 axis.

iScience·2026
Same author

The role of serendipity in our investigation of embryo implantation.

Developmental biology·2025
Same author

Tgif1 and Tgif2 Repress Expression of the RabGAP Evi5l.

Molecular and cellular biology·2016
Same author

Genetic and Molecular Analyses indicate independent effects of TGIFs on Nodal and Gli3 in neural tube patterning.

European journal of human genetics : EJHG·2016
Same author

The glands have it.

Biology of reproduction·2013
Same author

Loss of Tgif function causes holoprosencephaly by disrupting the SHH signaling pathway.

PLoS genetics·2012
Same journal

Editorial for special issue "When should mathematical models be used in biology".

Seminars in cell & developmental biology·2026
Same journal

Conserved machinery, divergent functions: evolutionary plasticity of the STK36/ULK4 kinase complex in ciliogenesis and signaling.

Seminars in cell & developmental biology·2026
Same journal

Chemical biology tools for studying tissue development.

Seminars in cell & developmental biology·2026
Same journal

Tetrahymena as a model organism for cilia research.

Seminars in cell & developmental biology·2026
Same journal

Emerging Concepts in Cardiovascular Development and Regeneration.

Seminars in cell & developmental biology·2026
Same journal

Endothelial origin of hematopoietic stem cells: Insights from new technologies and unresolved questions.

Seminars in cell & developmental biology·2026
See all related articles

Related Experiment Video

Updated: Mar 26, 2026

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo
08:19

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

Published on: October 17, 2011

13.5K

Tissue morphodynamics shaping the early mouse embryo.

Ann E Sutherland1

  • 1Department of Cell Biology, University of Virginia Health System, Charlottesville, VA 22908, United States.

Seminars in Cell & Developmental Biology
|January 29, 2016
PubMed
Summary
This summary is machine-generated.

Embryonic development transforms radial symmetry into an elongated vertebrate body plan through coordinated cell behaviors. Recent studies reveal the cellular and physical mechanisms driving early embryonic morphogenesis, especially in mouse models.

Keywords:
Axial elongationConvergent extensionGastrulationMorphogenesisMousePlanar cell polarity

More Related Videos

Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis
06:33

Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis

Published on: June 5, 2018

7.8K
Visualizing the Node and Notochordal Plate In Gastrulating Mouse Embryos Using Scanning Electron Microscopy and Whole Mount Immunofluorescence
09:36

Visualizing the Node and Notochordal Plate In Gastrulating Mouse Embryos Using Scanning Electron Microscopy and Whole Mount Immunofluorescence

Published on: November 6, 2018

9.5K

Related Experiment Videos

Last Updated: Mar 26, 2026

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo
08:19

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

Published on: October 17, 2011

13.5K
Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis
06:33

Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis

Published on: June 5, 2018

7.8K
Visualizing the Node and Notochordal Plate In Gastrulating Mouse Embryos Using Scanning Electron Microscopy and Whole Mount Immunofluorescence
09:36

Visualizing the Node and Notochordal Plate In Gastrulating Mouse Embryos Using Scanning Electron Microscopy and Whole Mount Immunofluorescence

Published on: November 6, 2018

9.5K

Area of Science:

  • Developmental biology
  • Cell biology
  • Biophysics

Background:

  • Vertebrate embryonic development involves significant tissue shape changes from an initial radial symmetry.
  • Understanding the cellular behaviors and physical forces driving morphogenesis is crucial for developmental biology.
  • Previous research established general principles, but detailed regional mechanisms remained to be elucidated.

Purpose of the Study:

  • To review recent advances in understanding the cellular basis of early vertebrate embryonic morphogenesis.
  • To highlight how region-specific cell behaviors contribute to establishing the basic embryonic form.
  • To integrate findings from various model systems, with a focus on the mouse embryo.

Main Methods:

  • Review of recent scientific literature and studies.
  • Analysis of new technical approaches enabling in-depth examination of mouse embryo morphogenesis.
  • Focus on cellular and physical biology principles governing tissue shape changes.

Main Results:

  • Emerging principles of cell and physical biology explain how specific cell behaviors generate regional tissue morphogenesis.
  • Integration of regional morphogenesis at the embryonic level is becoming clearer.
  • New techniques allow detailed investigation of cellular mechanisms in mouse embryonic development.

Conclusions:

  • Significant progress has been made in understanding the cellular basis of early embryonic morphogenesis.
  • Coordinated cell behaviors are fundamental to establishing the elongated vertebrate body plan.
  • Continued research, particularly with advanced imaging in model organisms like the mouse, is key to further insights.