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Related Concept Videos

Tight Junctions01:29

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Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
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The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
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Related Experiment Video

Updated: Mar 26, 2026

A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva
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Claudin-1 expressions decrease in pterygium with respect to normal conjunctiva.

Aysun Sanal Dogan1, Evrim Onder2, Ata Turker Arikok2

  • 1a Department of Ophthalmology , Ministry of Health and.

Cutaneous and Ocular Toxicology
|January 29, 2016
PubMed
Summary

Pterygium, a conjunctival growth, shows reduced claudin-1 expression. This suggests tight junction protein loss may contribute to pterygium development, warranting further research into their role.

Keywords:
Claudinconjunctivapterygiumtight junction

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Area of Science:

  • Ophthalmology
  • Cell Biology
  • Molecular Medicine

Background:

  • Pterygium is a fibrovascular growth of the conjunctiva onto the cornea.
  • Its proliferative nature suggests a potential role for tight junction proteins in its pathogenesis.

Purpose of the Study:

  • To investigate the expression of the tight junction protein claudin-1 in pterygium tissue compared to normal conjunctiva.
  • To determine if claudin-1 expression is altered in pterygium.

Main Methods:

  • Retrospective analysis of 28 pterygium surgery patients.
  • Immunohistochemical evaluation of claudin-1 expression in both lesional and normal conjunctiva from the same eye.
  • Statistical comparison of claudin-1 staining intensity and extent using the McNemar test.

Main Results:

  • A significant decrease in claudin-1 expression was observed in pterygium samples (10.8%) compared to normal conjunctiva (89.2%).
  • The reduction in claudin-1 expression in pterygium was statistically significant (p < 0.001).

Conclusions:

  • Loss of claudin-1 is implicated in the pathogenesis of pterygium.
  • Tight junction proteins may play a role in the invasive and recurrent characteristics of pterygium, requiring further investigation.