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Updated: Mar 26, 2026
Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
Published on: June 18, 2021
Subchorionic hematomas are increased in early pregnancy in women taking low-dose aspirin
Ashley Truong1, M Mercedes Sayago2, William H Kutteh3
1Department of Biochemistry and Molecular Biology, Rhodes College, Memphis, Tennessee.
Objective:
To determine the frequency of subchorionic hematomas (SCH) in first-trimester ultrasound examinations of patients with infertility and recurrent pregnancy loss (RPL) and in patients from a general obstetric population. To determine if the method of assisted reproduction utilized or the use of anticoagulants, such as heparin and aspirin (ASA), influenced frequency of SCH.
Design:
Prospective, cohort study.
Setting:
Fertility clinic and general obstetrics clinic.
Patient(S):
Five hundred and thirty-three women who were pregnant in the first-trimester.
Interventions:
Not applicable.
Main Outcome Measure(S):
Frequencies of subchorionic hematomas in women based on diagnosis, use of anticoagulants, and fertility treatment.
Result(S):
SCH were identified in 129/321 (40.2%) in the study group compared to 23/212 (10.9%) in the control group. Fertility diagnosis and the use of heparin did not appear to affect the frequency of SCH in the first trimester; however, SCH occurred at an almost four-fold increase in patients taking ASA compared to those not taking ASA, regardless of fertility diagnosis or method of fertility treatment.
Conclusion(S):
The use of ASA may be associated with an increased risk of developing a SCH during the first trimester. The increased frequencies of SCH in pregnancies of patients attending a fertility clinic compared to women from a general obstetrical practice was highly correlated with the use of ASA.
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