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Long Noncoding RNA MALAT-1 Can Predict Poor Prognosis: A Meta-Analysis.
Ruixue Tang1, Mengtong Jiang1, Lu Liang1
1Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang, China (mainland).
Summary
High MALAT-1 expression indicates poor prognosis in various cancers. This meta-analysis confirms its role as a potential prognostic indicator for overall and disease-free survival.
Area of Science:
- Molecular Biology
- Oncology
- Genetics
Background:
- MALAT-1 is a conserved nuclear long non-coding RNA (lncRNA).
- Overexpression of MALAT-1 is observed in several cancer types.
- Its prognostic significance in cancer requires further investigation.
Purpose of the Study:
- To evaluate MALAT-1 as a prognostic indicator in various human cancers.
- To synthesize evidence from existing studies through meta-analysis.
- To determine the association between MALAT-1 expression and patient survival outcomes.
Main Methods:
- Systematic literature search across 13 databases up to June 30, 2015.
- Meta-analysis of 17 studies including 1626 patients.
- Calculation of combined hazard ratios (HRs) with 95% confidence intervals (CIs) using fixed- or random-effects models.
- Quality assessment of studies using the Newcastle-Ottawa Scale (NOS).
Main Results:
- High MALAT-1 expression is significantly associated with poor overall survival (OS) (HR=1.84, 95% CI: 1.27-2.67).
- High MALAT-1 expression is also linked to poorer disease-free survival (DFS) (HR=2.37, 95% CI: 1.55-3.62).
- These associations were consistent across subgroups, including country-specific analyses (e.g., China: HR=1.85, 95% CI: 1.14-2.99).
Conclusions:
- Overexpression of MALAT-1 serves as a potential prognostic biomarker for diverse human cancers.
- MALAT-1 warrants further clinical investigation for its role in cancer prognosis.
- The findings support MALAT-1 as a valuable indicator of survival outcomes in cancer patients.
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