PREDICTORS OF INFLAMMATORY LOCAL RECURRENCE AFTER BREAST-CONSERVING THERAPY FOR BREAST CANCER: MATCHED CASE-CONTROL...

Area of Science:

• Oncology
• Surgical Oncology
• Breast Cancer Research

Background:

• Inflammatory local recurrence (ILR) following breast-conserving surgery for breast cancer (BC) is linked to poor outcomes.
• Risk factors contributing to ILR remain incompletely understood.

Purpose of the Study:

• To identify and analyze the clinico-pathological characteristics associated with inflammatory local recurrence (ILR) in breast cancer patients.
• To compare risk factors for ILR against non-inflammatory local recurrence (non-ILR), distant metastases, and disease-free outcomes.

Main Methods:

• A retrospective case-control study involving 12 patients with ILR, 24 with non-ILR, 24 with distant metastases, and 48 disease-free controls.
• Patients were treated between 2001 and 2010 with breast-conserving surgery, chemotherapy, and radiotherapy.
• Clinico-pathological data were analyzed using univariate and conditional logistic regression.

Main Results:

• Lymph node involvement, multifocality, c-erbB2 overexpression, and lymphovascular invasion (LVI) were significant univariate risk factors for ILR.
• Conditional logistic regression identified a significant association between ILR and the combination of LVI and high histopathological grade.
• A family history of breast cancer was associated with a higher likelihood of ILR compared to non-ILR and distant relapse.

Conclusions:

• High-grade breast cancer (BC) with lymphovascular invasion (LVI) increases the risk of inflammatory local recurrence (ILR), particularly in women with a family history of BC.
• Identifying these risk factors is crucial for developing targeted preventive strategies for high-risk breast cancer patients.