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Updated: Mar 26, 2026
Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
Published on: April 3, 2016
Photocrosslinking of Silk Fibroin Using Riboflavin for Ocular Prostheses
Matthew B Applegate1, Benjamin P Partlow1, Jeannine Coburn1
1Department of Biomedical Engineering, Tufts University, 4 Colby St., Medford, MA, 02155, USA.
Abstract:
A novel method to photocrosslink silk fibroin protein is reported, using riboflavin (vitamin B2) as a photoinitiator and the mechanism of crosslinking is determined. Exposure of riboflavin-doped liquid silk solution to light results in the formation of a transparent, elastic hydrogel. Several applications for this new material are investigated including corneal reshaping to restore visual acuity and photolithography.
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