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MicroRNAs01:22

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR
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Missing link between microRNA and prostate cancer.

Balraj Singh Gill1, Jimi Marin Alex2, Navgeet1

  • 1Centre for Biosciences, School of Basic and Applied Sciences, Central University of Punjab, Bathinda, 151001, India.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
|January 30, 2016
PubMed
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MicroRNAs (miRNAs) are key regulators of gene expression. Dysregulation of these molecules is linked to prostate cancer, highlighting their potential as therapeutic targets.

Keywords:
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Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are non-coding RNAs regulating gene expression in various organisms.
  • Aberrant miRNA levels, through genetic or epigenetic alterations, are implicated in disease pathogenesis, including cancer.
  • Emerging evidence points to a significant role for miRNAs in prostate cancer development and progression.

Purpose of the Study:

  • To review the current understanding of miRNA involvement in prostate cancer.
  • To explore the signaling pathways regulated by miRNAs in the context of prostate cancer.
  • To identify potential therapeutic molecular targets based on miRNA functions.

Main Methods:

  • Literature review of studies investigating miRNAs in prostate cancer.
  • Analysis of miRNA dysregulation mechanisms (deletions, overexpression, mutations, epigenetic silencing).
  • Examination of miRNA-controlled signaling pathways relevant to prostate cancer.

Main Results:

  • Numerous miRNA discoveries have advanced prostate cancer research, aiding in diagnosis and prediction.
  • While prediction has improved, effective treatment strategies for prostate cancer remain elusive.
  • miRNAs are involved in various cellular processes crucial to prostate cancer.

Conclusions:

  • miRNA dysregulation is a critical factor in prostate cancer.
  • Understanding miRNA-mediated signaling pathways is essential for identifying novel therapeutic targets.
  • Further research into miRNAs may unlock effective treatment strategies for prostate cancer.