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Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
Published on: October 20, 2021
[Spatial data based study of distribution of hepatitis C in Chongqing]
Lu Tang1, Yan Zhang1, Dianguo Xing2
1School of Public Health and Management, Center for Research of Medicine and Social Development, The Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing 400016, China.
Objective:
To understand the spatial distribution of hepatitis C in Chongqing and its influencing factors.
Methods:
The surveillance data of hepatitis C in 38 counties in Chongqing from January 2010 to December 2014 were collected, and spatial autocorrelation analysis and spatial regression analysis were conducted respectively by using software GeoDa 1.6.7.
Results:
The reported incidence of hepatitis C in Chongqing ranged from 7.3/100,000 to 13.6/100,000 during 2010-2014, with the annual reported incidence of 10.3/100,000. The global Moran's I values were 0.478, 0.503, 0.529, 0.438, 0.406 respectively (P<0.05). The local spatial autocorrelation analysis indicated there were 6, 4, 7, 5 and 6 areas with high incidences of hepatitis C in 2010, 2011, 2012, 2013 and 2014 respectively. Spatial regression analysis revealed that the reported incidence of hepatitis C in Chongqing was associated with the urbanization rate (Z=2.126, P=0.033).
Conclusions:
The spatial distribution of hepatitis C in Chongqing from 2010 to 2014 was highly clustered. The hot spot of hepatitis C were mainly in the core areas and extended areas with well-developed economy, however the cold spot were in southeastern ecological reserve area with less developed economy. Urbanization had a certain positive influence on the distribution of hepatitis C in Chongqing.
