Related Experiment Video
Updated: Mar 26, 2026

Surgically Induced Cardiac Volume Overload by Aortic Regurgitation in Mouse
Published on: August 30, 2022
Left ventricular volumes by echocardiography in chronic aortic and mitral regurgitations
Odd Bech-Hanssen1,2,3,4, Christian Lars Polte1,3, Kerstin M Lagerstrand5,6
1a Department of Cardiology , Sahlgrenska Academy at the University of Gothenburg , Gothenburg , Sweden ;
Insights
Echocardiography can help diagnose severe aortic or mitral regurgitation by measuring left ventricular (LV) volumes. New cut-off values for LV end-diastolic volume index are proposed for accurate assessment.
Area of Science:
- Cardiology
- Medical Imaging
- Echocardiography
Background:
- Defining cut-off values for left ventricular (LV) dimensions in severe valve regurgitation is crucial.
- Current echocardiographic methods lack precise criteria for severe chronic aortic regurgitation (AR) and mitral regurgitation (MR).
Purpose of the Study:
- To establish echocardiographic cut-off values for LV dimensions that indicate severe chronic AR or MR.
- To validate these values against cardiovascular magnetic resonance (CMR) findings.
Main Methods:
- Eighty-three patients with moderate to severe AR or MR underwent 2D echocardiography (2DE), real-time 3D echocardiography (RT3DE), and CMR.
- Hemodynamic significance was confirmed by reduced end-diastolic volume (EDV) and symptom relief post-surgery.
Main Results:
- Strong correlations were found between CMR-derived EDV and echocardiographic EDV (R=0.95 for 2DE, R=0.91 for RT3DE).
- Specific EDV index cut-offs were identified: >87/104 ml/m² for AR and >69/87 ml/m² for MR using 2DE/RT3DE.
- LV linear dimensions were not effective in identifying severe regurgitation.
Conclusions:
- Echocardiographic LV volumes can aid in diagnosing severe chronic regurgitation.
- These established cut-off values provide valuable diagnostic support.
- Consideration of other causes for LV enlargement is important in clinical practice.
Abstract:
Objectives Cut-off values for left ventricular (LV) dimensions indicating severe valve regurgitation have not been defined. The aim of this study was to establish echocardiographic cut-off values for LV dimensions indicating severe chronic aortic (AR) or mitral (MR) regurgitation. Design The hemodynamic significance was confirmed by documented reduction of end-diastolic volume (EDV) and symptom relief after surgery. Eighty-three patients with moderate or severe regurgitation (AR, n = 41; MR, n = 42) without other cardiac conditions underwent prospectively two-dimensional (2DE), real-time three-dimensional (RT3DE) echocardiography and cardiovascular magnetic resonance (CMR) exams within 4 h. Results The relationship between EDVCMR and EDV2DE and EDVRT3DE were strong (R 0.95 and 0.91). EDV index cut-offs for 2DE/RT3DE >87/104 ml/m(2) identified AR patients with severe regurgitation with a positive likelihood ratio (PLR) of 5.0/5.0. The corresponding in patients with MR EDV index cut-offs were >69/87 ml/m(2) with a PLR of 14.9/5.5. LV linear dimensions could not identify patients with severe regurgitation. Conclusions LV volumes by echocardiography can support the diagnosis of severe chronic regurgitation. Importantly, other causes for LV enlargement have to be considered.
More Related Videos
11:16In vitro Assessment of Aortic Regurgitation Using Four-Dimensional Flow Magnetic Resonance Imaging
Published on: February 25, 2022
11:50High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
Published on: July 9, 2010
Related Concept Videos
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Mitral Regurgitation I: Introduction
Aortic Regurgitation I: Introduction
Mitral Regurgitation II: Clinical Features and Diagnostic Tests
Aortic Regurgitation III: Medical Management
Mitral Regurgitation IV: Nursing Management