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Updated: Mar 26, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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Allosteric Pathways in the PPARγ-RXRα nuclear receptor complex

Clarisse G Ricci1, Rodrigo L Silveira1, Ivan Rivalta2,3

  • 1Institute of Chemistry, University of Campinas-UNICAMP, Cx. P. 6154, Campinas SP 13084-862, Brazil.

Scientific Reports
|January 30, 2016
PubMed
Summary

Allostery in nuclear receptor (NR) complexes, like the peroxisome proliferator-activated/retinoid X receptor, is key for drug development. Understanding these DNA-binding protein dynamics can lead to new treatments for metabolic diseases.

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