PPM1D Mosaic Truncating Variants in Ovarian Cancer Cases May Be Treatment-Related Somatic Mutations

Paul D P Pharoah¹, Honglin Song¹, Ed Dicks¹+29

• ¹Affiliations of authors:CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory , Cambridge, UK (PDPP, HS, ED, PH, CB); Department of Preventive Medicine, Keck School of Medicine , USC/NorrisComprehensive Cancer Center, University of Southern California , CA (MPI, SAG, SJR); Peter MacCallum Cancer Centre, East Melbourne , Victoria , Australia (KA, AOCSG, DDB); Westmead Millennium Institute, Westmead Hospital , Sydney , Australia (AOCSG); The QIMR Berghofer Medical Research Institute , Brisbane , Australia (AOCSG); Gynaecology Research Unit, Hannover Medical School , Hannover , Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School , Hannover , Germany (NB); Mother and Child Hospital , Minsk , Belarus (NB); Department of Health Science Research, Division of Epidemiology, Mayo Clinic , Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center , KS (BLF); Gynaecological Cancer Research Centre, Women's Cancer, Institute for Women's Health, University College London , London, UK (AGM, MW, UM); Clinics of Obstetrics and Gynaecology, Hannover Medical School , Hannover , Germany (PH); Department of Gynecological Oncology, Roswell Park Cancer Institute , Buffalo, NY (SL, SP, KO); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center , Los Angeles, CA (JL, BYK); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine , Stanford, CA (VM, WS, ASW); Department of Cancer Prevention and Control, Roswell Park Cancer Institute , Buffalo, NY (KBM, LSC); Department of Obstetrics and Gynecology, Duke University Medical Center , Durham, NC (OCAC); Department of Biochemistry and Molecular Biology, University of Melbourne , Melbourne, Victoria , Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne , Melbourne, Victoria , Australia (DDB); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London , London, UK (DDB).