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KIR2DL4 expression rather than its single nucleotide polymorphisms correlates with pre-eclampsia
Dandan Wang1, Yuan Tian1, Yanhui Zhao1
1Department of Obstetrics and Gynecology, The Second Hospital of Jilin University Changchun 130041, China.
Objective:
To evaluate the single nucleotide polymorphisms and expression of KIR2DL4 (killer cell immunoglobulin-like receptors) gene in pre-eclampsia patients.
Methods:
KIR2DL4 gene polymorphisms were detected in 100 patients with pre-eclampsia and 100 healthy pregnant women, respectively, by using PCR-SS. Then, the expression of KIR2DL4 was measured in 5 cases of placentas tissues with pre-eclampsia and normal pregnancies by using qRT-PCR.
Results:
Compared with healthy controls, 16 loci of single nucleotide polymorphisms (SNP) were identified in pre-eclampsia patients, including 7 new polymorphisms loci. But, no significant difference was found in genotype distributions and allele frequencies in pre-eclampsia and controls (P>0.05). However, qRT-PCR results showed that KIR2DL4 mRNA in placenta tissues with pre-eclampsia was significantly lower than those with normal pregnancy, and the difference was statistically significant.
Conclusion:
Decreased level of KIR2DL4 rather than its SNP is correlated with the susceptibility of pre-eclampsia.
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